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Updated imaging markers in cerebral amyloid angiopathy: What radiologists need to know.
Jpn J Radiol
December 2024
Department of Radiology, Mie University Graduate School of Medicine, 2-174, Edobashi, Tsu, Mie, 514-8507, Japan.
Cerebral amyloid angiopathy (CAA) is an age-related small vessel disease pathologically characterized by the progressive accumulation of amyloid-beta (Aβ) peptide in cerebrovascular walls, affecting both cortical and leptomeningeal vessels. Amyloid deposition results in fragile vessels, which may lead to lobar intracerebral hemorrhage (ICH) and cognitive impairment. To evaluate the probability and severity of CAA, the imaging markers depicted on CT and MRI techniques are crucial, as brain pathological examination is highly invasive.
View Article and Find Full Text PDFClinical Insights into Neurosyphilis Patients with Leptomeningeal Enhancement of Spinal Cord.
Neuropsychiatr Dis Treat
December 2024
National Center for Infectious Disease, Beijing Ditan Hospital Capital Medical University, Beijing, People's Republic of China.
Background And Objectives: This study aims to report the clinical, biological, and imaging features of cross-sectional study of neurosyphilis patients with leptomeningeal enhancement of spinal cord. Here, 51 neurosyphilis patients with leptomeningeal enhancement of spinal cord positivity are described, offering a promise in terms of early diagnosis, thereby enabling timely detection and treatment.
Methods: We retrospectively included all neurosyphilis patients enrolled in this study from December 2019 to January 2024.
Pathology of rheumatoid meningitis: A report of 5 cases highlighting the importance of clinical correlation.
Ann Diagn Pathol
February 2025
Department of Pathology, University of Colorado Health Science Center, Anschutz Medical Campus, Aurora, CO, USA; Department of Neurosurgery, University of Colorado Health Science Center, Anschutz Medical Campus, Aurora, CO, USA; Department of Neurology, University of Colorado Health Science Center, Anschutz Medical Campus, Aurora, CO, USA.
Rheumatoid meningitis (RM) presents with sufficiently wide-ranging, but non-specific, symptoms and neuroimaging features of pachy- and/or leptomeningeal thickening that it may be indistinguishable from subacute infectious meningitis. RA diagnosis variably antedates RM and serological confirmation by rheumatoid factor and anti-citrullinated peptide antibodies may not be present preoperatively. Thus, meningeal biopsy may be undertaken.
View Article and Find Full Text PDFNeuroradiological Findings in Cerebral Amyloid Angiopathy with a Particular Consideration of the Boston Criteria 2.0: An Imaging Review.
Biomolecules
November 2024
Department of Neurology, University Medical Centre Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany.
In the elderly, cerebral amyloid angiopathy (CAA) is the most common cause for intracranial lobar hemorrhages. CAA is caused by the accumulation of amyloid-β fibrils in cortical and leptomeningeal vessels. In 2022, the Boston Criteria 2.
View Article and Find Full Text PDFCentral nervous system crystal-storing histiocytosis: A case report and literature review.
Eur J Neurol
January 2025
Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
Article Synopsis
- Crystal-storing histiocytosis (CSH) is a rare condition where abnormal protein crystals accumulate in the body, and when it affects the CNS, it can cause persistent imaging abnormalities.* -
- The study describes one local case of CNS CSH alongside 10 other cases, noting that 9 had brain parenchyma involvement and some cases were linked to conditions like lymphoma.* -
- While CNS CSH is uncommon, comprehensive evaluation for related malignancies is crucial, and treatment focuses on addressing these underlying conditions.*
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