Cadmium telluride quantum dots (CdTe QDs) exist in the environment due to the abandonment of products. There is a potential risk to organisms and toxic mechanism is worth exploring. In this study, 12.5 μmol/Kg body weight CdTe QDs triggered systemic and local inflammatory response in mice and activated macrophages, then the mechanism of activating macrophages to overexpress IL-1β and IL-6 was explored. RAW264.7 macrophages were used, and after macrophages exposing to 1 μM CdTe QDs for 24 h, oxidative stress occurred. Further investigation found that CdTe QDs triggered ferroptosis in RAW264.7 cells. And deferoxamine mesylate alleviated the excessive lipid hydroperoxide caused by QDs. Mechanistically, CdTe QDs-provoked decrease of nuclear factor erythroid 2-related factor 2 (NRF2) elicited phosphorylation of extracellular regulated protein kinases1/2 (ERK1/2) and then activated ferritinophagy, which made ferritin heavy chain 1 (FTH1) degraded in lysosome and proteasome to release free iron ions to initiate ferroptosis in macrophages. This paper updates the mechanism of macrophage activation by CdTe QDs with regard to ferritinophagy, and more importantly, identifies the key role of NRF2 and ERK1/2. Our research extends the role of ferroptosis in inflammatory responses triggered by nanoparticles (NPs) in macrophages and provides insightful reference for toxicity assessment of NPs.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jhazmat.2022.129043 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Excitation wavelength-dependent quantum yield in water-soluble CdTe quantum dots.
Nanoscale
January 2025
School of Chemical Sciences, Indian Institute of Technology Mandi, H.P. 175075, India.
The quantum yield (QY) of semiconductor quantum dots (QDs) is severely hampered by the inherent fluorescence intermittency. The QY of QDs typically increases with an increase in the excitation wavelength. Here, we present a distinctive behavior, where the QY is found to decrease with an increase in the excitation wavelength in water-soluble CdTe QDs (CQDs).
View Article and Find Full Text PDFVisual and fluorescence dual mode platform for sensitive and accurate screening of breast carcinoma.
Biosens Bioelectron
December 2024
TCM and Ethnomedicine Innovation & Development International Laboratory, School of Pharmacy, Hunan·University of Chinese Medicine, Changsha, China. Electronic address:
Compared to single-mode detection, dual-mode sensing strategies have garnered increasing attention from researchers due to their superior detection accuracy and reliability. Exosomes, as non-invasive biomarkers, hold significant potential for disease diagnosis. However, sensitive and precise detection of exosomes still presents considerable technical challenges.
View Article and Find Full Text PDFHydrogel biomimetic skin inspired by human skin for resisting bacterial infection.
Biomater Adv
March 2025
Department of Basic, Zhejiang Pharmaceutical University, Ningbo 315500, PR China. Electronic address:
The flexible surface and chemical compatibility of hydrogels render them particularly appealing for research and development in antibacterial materials. However, designing tough hydrogels with multiple antibacterial mechanisms simultaneously remains a challenge. Inspired by the human skin, a hydrogel with bacterial antifouling, detection, and inactivation functions has been prepared using zwitterionic [2-(methylacrylyl) ethyl] dimethyl-(3-propyl sulfonate) ammonium hydroxide (SBMA) as the matrix and cadmium telluride quantum dots functionalised with cysteamine (CA-CdTe QDs) as the filler through micelle copolymerisation technology, achieving the integration of multiple antimicrobial mechanisms.
View Article and Find Full Text PDFAcute toxicity and biodistribution assessment of quantum dots conjugated to lectins from leaves (SteLL) and sarcotesta (PgTeL).
Drug Chem Toxicol
November 2024
Centro Regional de Ciências Nucleares do Nordeste, Recife, Pernambuco, Brazil.
This work reports the investigation of telluride cadmium quantum dots (CdTe QDs) conjugated to plant lectins from (SteLL) and (PgTeL) for acute toxicity and genotoxicity in healthy mice and 24-h biodistribution in sarcoma 180-bearing animals. Acute toxicity data indicated their safety, despite some histopathological alterations. Comet assay revealed that the QDs-PgTeL group presented a higher damage index and frequency of damage than the negative control.
View Article and Find Full Text PDFBioluminescence Resonance Energy Transfer Sensor with Tunable Conjugation Efficiency for Highly Sensitive Detection of Superoxide Anion in Tumors.
ACS Appl Bio Mater
December 2024
Key Laboratory of Biomedical Engineering of Fujian Province University/Research Center of Biomedical Engineering of Xiamen, Department of Biomaterials, College of Materials, State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Xiamen University, Xiamen 361005, P. R. China.
Superoxide anion (O) is a highly reactive oxygen species (ROS) within tumor cells, and its abnormal concentrations can lead to various diseases such as cancer, inflammation, and premature aging disorders. Here, we obtained a series of bioluminescence resonance energy transfer (BRET) systems that can be used for sensitive and specific detection of O by varying the type and reaction time of quantum dots (QDs) and combining them with different concentrations of recombinant aequorin. Among them, the recombinant aequorin-conjugated CdTe/CdSe QDs had the highest conjugation efficiency as the Aeq-QD BRET sensor, which has a remarkable energy transfer efficiency of 35.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!