AI Article Synopsis
- Radiation resistance in lung adenocarcinoma (LUAD) is a major issue impacting patient survival, and histone H2A variants may play a role in influencing tumor radiosensitivity.
- Analysis of the TCGA database revealed that the histone variant H2A.Z.1 is linked to LUAD progression and worse patient outcomes.
- Experimental assays indicated that H2A.Z.1 enhances cell migration, invasion, and overall radiation resistance, suggesting that targeting this histone variant alongside radiation therapy could be a promising treatment strategy for LUAD.
Article Abstract
Radiation resistance reduces patient survival and is an important challenge in treating lung adenocarcinoma (LUAD). Previous studies have shown that histone H2A variants can affect the radiosensitivity of tumors; however, the main role of histone H2A variants in LUAD remains unclear. Using the TCGA database, we found that histone H2A variant H2A.Z.1 is positively associated with the progression and poor prognosis of LUAD. Colony formation, scratch wound-healing, and transwell assays as well as Western blot were performed to assess the role of H2A.Z.1 in vitro. Results suggested that H2A.Z.1 promoted cell migration and invasion, epithelial-mesenchymal transition, stemness, and radiation resistance in LUAD cells. Targeting H2A.Z.1 in combination with radiation therapy could be a potential therapeutic approach for radiation resistant LUAD.
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| http://dx.doi.org/10.1016/j.bbrc.2022.03.141 | DOI Listing |
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