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Differential suppression of hippocampal network oscillations by neuropeptide Y.
Neuropharmacology
December 2024
Institute of Physiology and Pathophysiology, Heidelberg University, Im Neuenheimer Feld 326, 69120 Heidelberg, Germany.
Neuropeptide Y (NPY) is the most abundant neuropeptide in the brain. It exerts anxiolytic and anticonvulsive actions, reduces stress and suppresses fear memory. While its effects at the behavioral and cellular levels have been well studied, much less is known about the modulation of physiological activity patterns at the network level.
View Article and Find Full Text PDFInosine exerts dopaminergic neuroprotective effects via mitigation of NLRP3 inflammasome activation.
Neuropharmacology
December 2024
College of Pharmacy, Yeungnam University, Gyeongsan, Gyeongbuk, Republic of Korea. Electronic address:
Neuroinflammation plays a crucial role in the pathogenesis of Parkinson's disease (PD). Transformation of pro-interleukin (IL)-1β into a mature IL-1β via active inflammasome may be related to the progression of PD. Therefore, the modification of inflammasome activity may be a potential therapeutic strategy for PD.
View Article and Find Full Text PDFPotential antioxidant properties and computational molecular interactions of Moringa oleifera against abamectin-induced oxidative stress in rat erythrocytes and brain.
Chem Biodivers
December 2024
University of Badji Mokhtar Annaba Department of Biochemistry, Biochemistry, Annaba, 213, Annaba, ALGERIA.
The current study was conducted to explore the phytochemical composition and in vitro antioxidant activities of Moringa oleifera (MO) leaf aqueous extract, as well as its in vivo modulatory effects on abamectin (ABM) induced oxidative stress in rat erythrocytes and brain. Animals were randomly divided into four groups. The first group served as a control and received distilled water by gavage.
View Article and Find Full Text PDFSuccinate Regulates Exercise-Induced Muscle Remodelling by Boosting Satellite Cell Differentiation Through Succinate Receptor 1.
J Cachexia Sarcopenia Muscle
February 2025
Clinical Nutrition Service Center, Department of General Surgery, Nanjing Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China.
Background: Skeletal muscle remodelling can cause clinically important changes in muscle phenotypes. Satellite cells (SCs) myogenic potential underlies the maintenance of muscle plasticity. Accumulating evidence shows the importance of succinate in muscle metabolism and function.
View Article and Find Full Text PDFProlonged survival by combination treatment with a standardized herbal extract from Japanese Kampo-medicine (Juzentaihoto) and gemcitabine in an orthotopic transplantation pancreatic cancer model.
Front Oncol
December 2024
Clinic for Gastroenterology and Gastrointestinal Oncology, University Medical Center Göttingen (UMG), Göttingen, Germany.
Pancreatic ductal adenocarcinoma (PDAC) is characterized by its poor prognosis. Traditional Japanese herbal medicine (Kampo), such as Juzentaihoto (a standardized combination of 10 herbal extracts), has shown immune modulatory effects, modulation of microcirculation, and amelioration of fatigue. It is administered to patients to prevent deterioration of cachexia and counteract side effects of chemotherapy.
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