Efficacy and safety of Corbrin Capsule on malnutrition, inflammation, and atherosclerosis syndrome in patients with uremia: systematic review and meta-analysis.

Background: Uremia is a clinical syndrome caused by the development of chronic renal failure to the end-stage. Corbrin Capsule has the effect of tonifying the lungs and kidneys and improving the essence and qi, which can improve the metabolic disorders of the body. However, there is currently no systematic evaluation of the efficacy of Corbrin Capsule in the treatment of uremia malnutrition, inflammation, and atherosclerosis (MIA) syndrome. This paper aiming to provide a reference for improving the prognosis of uremic MIA patients.

Methods: According to the PICOS principle, the literature inclusion and exclusion criteria were formulated. The databases such as PubMed, Web of Science, Embase, and Cochrane Library were searched by computer using "Corbrin Capsule", "uremia", "MIA syndrome", and "kidney function" as search items. The outcome indicators were body mass index (BMI), C-reactive protein (CRP), blood urea nitrogen (BUN), and serum creatinine (sCr). Subsequently, the Cochrane Reviewer's Handbook 4.2.5 was adopted to assess the literature quality. The conventional treatment combined with Corbrin Capsule was defined as MIA/treatment group, and the conventional treatment was defined as the control group. The Review Manager (RevMan) 5.3 software was used to conduct a meta-analysis of the experimental data.

Results: A total of 6 suitable included articles were selected, including 894 patients. The included literature was analyzed and found that there was no obvious publication bias. According to the results of meta-analysis, the total BMI score was mean difference (MD) [95% confidence interval (CI)]: -0.10 (-3.44 to 3.24) with Z=0.06 and P=0.95. The CRP total score was MD (95% CI): 1.40 (0.34 to 2.46) with Z=2.58 and P=0.010. The BUN index was MD (95% CI): -1.15 (-3.05 to 0.75) with Z=1.18, P=0.24. Analysis result of sCr index data was MD (95% CI): -72.82 (-202.16 to 56.52) with Z=1.10 and P=0.27.

Discussion: Corbrin Capsule can effectively improve the relevant physiological indicators of patients with uremic MIA syndrome. However, the outcome indicators included in this study were insufficient, and it is necessary to further expand the sample size and outcome indicators in the future.