Acute liver failure secondary to therapeutic paracetamol dosing in an extremely preterm neonate.

BMJ Case Rep

Department of Paediatrics and Child Health, University of Otago, Wellington, New Zealand.

Published: May 2022

AI Article Synopsis

  • A case report discusses a preterm infant who developed acute liver failure after receiving standard doses of paracetamol for patent ductus arteriosus closure.
  • The infant experienced jaundice, severe hepatitis, and issues with blood clotting after 5 days of treatment.
  • Administration of N-acetyl cysteine was successful in restoring the infant's health completely.

Article Abstract

We report the first case of standard therapeutic dose paracetamol for patent ductus arteriosus closure causing acute liver failure in an extremely preterm infant. After 5 days of treatment, he presented with jaundice, acute severe hepatitis and coagulopathy. Treatment with N-acetyl cysteine resulted in full recovery.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9083392PMC
http://dx.doi.org/10.1136/bcr-2021-245406DOI Listing

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