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Spatiotemporal Analysis of Mesenchymal Stem Cells Fate Determination by Inflammatory Niche Following Soft Tissue Injury at a Single-Cell Level.
Adv Sci (Weinh)
November 2024
Department of Pathophysiology, School of Basic Medical Sciences, Anhui Medical University, Hefei, 230032, China.
Heterotopic ossification (HO), often arising in response to traumatic challenges, results from the aberrant osteochondral differentiation of mesenchymal stem cells (MSCs). Nevertheless, the impact of trauma-induced inflammatory exposure on MSC fate determination remains ambiguous. In this study, the cellular diversity within inflammatory lesions is elucidated, comprising MSCs and several innate and adaptive immune cells.
View Article and Find Full Text PDFRelationship between the extent of vascular injury and the evolution of surgically induced osteochondrosis lesions in a piglet model.
PLoS One
August 2024
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, United States of America.
Article Synopsis
- Osteochondritis dissecans (OCD) is a joint disease that occurs when there are defects in the bone and cartilage, often stemming from a lack of blood supply, leading to necrosis of the cartilage (osteochondrosis).
- A study was conducted using a piglet model to investigate how different levels of blood supply interruption (complete vs. partial) affect the development and healing of osteochondral lesions.
- Results showed that complete devascularization led to larger lesions compared to partial devascularization, indicating that the severity of blood supply disruption plays a key role in lesion progression and healing outcomes.
Functionally graded hydrogels with opposing biochemical cues for osteochondral tissue engineering.
Biofabrication
May 2024
Department of Biological Sciences and Bioengineering, Indian Institute of Technology-Kanpur, Kanpur 208016, Uttar Pradesh, India.
Osteochondral tissue (OC) repair remains a significant challenge in the field of musculoskeletal tissue engineering. OC tissue displays a gradient structure characterized by variations in both cell types and extracellular matrix components, from cartilage to the subchondral bone. These functional gradients observed in the native tissue have been replicated to engineer OC tissue.
View Article and Find Full Text PDFPhase separation of SHP2E76K promotes malignant transformation of mesenchymal stem cells by activating mitochondrial complexes.
JCI Insight
March 2024
Department of Pathophysiology, School of Basic Medical Sciences, Stem Cell Regeneration Research Center, Anhui Medical University, Hefei, China.
Mesenchymal stem cells (MSCs), suffering from diverse gene hits, undergo malignant transformation and aberrant osteochondral differentiation. Src homology region 2-containing protein tyrosine phosphatase 2 (SHP2), a nonreceptor protein tyrosine phosphatase, regulates multicellular differentiation, proliferation, and transformation. However, the role of SHP2 in MSC fate determination remains unclear.
View Article and Find Full Text PDFEvaluation of rabbit adipose derived stem cells fate in perfused multilayered silk fibroin composite scaffold for Osteochondral repair.
J Biomed Mater Res B Appl Biomater
March 2024
National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran.
Development of osteochondral tissue engineering approaches using scaffolds seeded with stem cells in association with mechanical stimulations has been recently considered as a promising technique for the repair of this tissue. In this study, an integrated and biomimetic trilayered silk fibroin (SF) scaffold containing SF nanofibers in each layer was fabricated. The osteogenesis and chondrogenesis of stem cells seeded on the fabricated scaffolds were investigated under a perfusion flow.
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