[Pathogenetic and chemical-laboratory aspects of age-associated vascular diseases of older and senile persons (review).].

Cardiovascular diseases, including atheroscleroscoronary and cerebral arteries, are an important medical and social problem of the population, especially among the elderly and seniors. The proportion of older persons is about 80% among deaths from complications of atherosclerosis and over 60% among all detected cases of myocardial infarction in the Russian Federation. Age changes in the body negatively affect the course of the disease. Analysis of the scientific literature found age-related morphofunctional metamorphoses of the vascular wall, blood forms, lipid and carbohydrate metabolism, immune system, redox balance, microbiota. These changes exacerbate atherogenesis, as atherosclerosis is found to be a multi-factor disease with a wide range of causal relationships. Research demonstrates the possibility of developing measures that can affect different pathogenetic links of the disease. A study of transendothelial transport of lipoproteins, the role of different macrophage populations on the course of atherosclerosis, seems promising. Preventive measures aimed at preventing, early detection of both atherosclerosis itself and its complications, as well as expanding the spectrum of targeted therapy, can significantly improve the quality of life of the older generation.