AI Article Synopsis
Article Abstract
Ion mobility spectrometry/mass spectrometry (IMS/MS) is widely used to study various levels of protein structure. Here, we review the current state of affairs in -trapped ion mobility spectrometry/mass spectrometry (TIMS/MS). Two different TIMS/MS instruments are discussed in detail: the first TIMS/MS instrument, constructed from coaxially aligning two TIMS devices; and an orthogonal TIMS/MS configuration that comprises an ion trap for irradiation of ions with UV photons. We discuss the various workflows the two TIMS/MS setups offer and how these can be used to study primary, tertiary, and quaternary structures of protein systems. We also discuss, from a more fundamental perspective, the processes that lead to denaturation of protein systems in TIMS/MS and how to soften the measurement so that biologically meaningful structures can be characterised with TIMS/MS. We emphasize the concepts underlying TIMS/MS to underscore the opportunities tandem-ion mobility spectrometry methods offer for investigating heterogeneous samples.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9914546 | PMC |
| http://dx.doi.org/10.1039/d2an00335j | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Functionalized Polyethylene Separators with Efficient Li-Ion Transport Rate for Fast-Charging Li-Ion Batteries.
ACS Appl Mater Interfaces
December 2024
School of Materials Science and Engineering, Xihua University, Chengdu, Sichuan 610039, China.
Fast-charging lithium-ion batteries (LIBs) are the key to solving the range anxiety of electric vehicles. However, the lack of separators with high Li transportation rates has become a major bottleneck, restricting their development. In this work, the electrochemical performance of traditional polyethylene separators was enhanced by coating AlO nanoparticles with a novel green binder.
View Article and Find Full Text PDFMOF-Derived Hollow C, N-Doped CoO Dodecahedral Nanostructure Enwrapped with MgInS Nanosheets for Enhanced Photocatalytic N Reduction.
Inorg Chem
December 2024
Department of Chemistry, National Institute of Technology, Rourkela 769008, Odisha, India.
Design of hierarchical hollow nanoheterostructure materials through interfacial and defect engineering is an innovative approach for achieving optimal charge separation dynamics and photon harvesting efficiency. Herein, we have described a facile technique to fabricate hollow MOF-derived C, N-doped-CoO (C, N-CoO) dodecahedral particles enwrapped with MgInS nanosheets for enhanced N reduction performance. ZIF-67 was initially used as a sacrificial template to prepare hollow C, N-CoO using a carbonization route followed by low-temperature calcination treatment.
View Article and Find Full Text PDFMolecular Insights into Binary Ionic Melts of Protic Ionic Liquid 1,2,4-Triazolium Methanesulfonate and Methanesulfonic Acid Electrolytes.
J Phys Chem B
December 2024
Department of Chemistry, J. C. Bose University of Science and Technology, YMCA, Faridabad 121006, India.
Binary ionic melts formed by a protic ionic liquid (PIL) 1,2,4-triazolium methanesulfonate ([TAZ][MS]) dissolved in methanesulfonic acid are studied as non-stoichiometric electrolytes. The composition-driven structure-property relationship of methanesulfonic acid is explored at varying molar fraction ratios from 0/100 to 10/90, 20/80, and 30/70 by the addition of 1,2,4-triazolium methanesulfonate [TAZ][MS] IL. To unveil molecular characteristics of these mixtures of [TAZ][MS] PIL and CHSOH, we performed classical molecular dynamics simulations at varying temperatures from 293 to 303, 363, and 423 K.
View Article and Find Full Text PDFAprotic electrolytes beyond organic carbonates: transport properties of LiTFSI solutions in sulphur based solvents.
ChemSusChem
December 2024
University of Rome La Sapienza, Department of Chemistry, P.le A. Moro 5, 00185, Rome, ITALY.
This work illustrates a physico-chemical study of the structural, dynamic, and transport properties of electrolytes made of LiTFSI solutions in sulphoxide and sulphone solvent mixtures. Experimental measurements, by Raman and NMR spectroscopies, as well as electrochemical impedance spectroscopy, reveal the formation of a variety of ionic aggregates depending on the solvent composition that significantly affect the ion mobility and conductivity of the electrolyte. Mixtures containing tetrahydrothiophene-1-oxide exhibit a larger ion mobility due to a rapid exchange mechanism between solvent molecules, whereas the use of tetramethylene sulphone favors the formation of ionic aggregates due to the strong dipolar interactions between solvent molecules.
View Article and Find Full Text PDFDevelopment of urea-bridged cyclic dominant negative pneumococcus competence-stimulating peptide analogs.
Org Biomol Chem
December 2024
Department of Chemistry, University of Nevada, Reno, 1664 North Virginia Street, Reno, NV 89557, USA.
Cyclization is a widely used approach to exert conformational restraint on linear peptide sequences. Herein, urea bridge chemistry was deployed to achieve side chain-to-side chain peptide cyclization on the CSP1-E1A peptide scaffold. To determine the effects of ring size and bridge position on the overall peptide conformation and find the ideal area within the CSP sequence for cyclization, we performed biological evaluation as well as secondary structure analysis on all the cyclic analogs.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!