AI Article Synopsis
- The suprachiasmatic nucleus (SCN) helps regulate daily rhythms by integrating light and signals from the body, but the impact of nutrients and feeding on this function is still debated.
- Time-restricted feeding (TRF) during early hours significantly altered mouse locomotor behavior and increased wakefulness, activating specific neuron signals in the SCN.
- RNA analysis revealed that TRF boosted expression of Insulin-like Growth Factor 2 (IGF2) and affected ion transport mechanisms, indicating that the IGF2-KCC2 pathway may be key in mediating behavior changes from restricted feeding.
Article Abstract
The suprachiasmatic nucleus (SCN) integrates light and systemic signals from peripheral tissues to coordinate physiology and behavior daily rhythms. However, the contribution that nutrients and feeding patterns provide to the SCN network regulation remains controversial. Here, we found that time-restricted feeding (TRF) in ZT0-4 (Zeitgeber Time) generates a robust and long-term shift in locomotor behavior and increased wakefulness. Intracellular Ca signals in SCN GABAergic neurons of freely moving mice showed significant activation after ZT0-4 TRF treatment. Furthermore, RNA-seq profiling of SCN showed that TRF during ZT0-4 increased Insulin-like Growth Factor 2 () expression and dysregulated ion transporters, including the downregulation of . SCN neuron-specific loss of function of amplified ZT0-4 TRF induced aftereffect. Moreover, overexpression of IGF2 in SCN GABAergic neurons extended the locomotion range, mirroring the TRF aftereffect. In summary, our study showed that the IGF2-KCC2 pathway plays an important role for TRF induced behavior changes.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062755 | PMC |
| http://dx.doi.org/10.1016/j.isci.2022.104267 | DOI Listing |
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