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A biophysical basis for the spreading behavior and limited diffusion of Xist.

Cell

January 2025

Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Genetics, Harvard Medical School, Boston, MA, USA. Electronic address:

Xist RNA initiates X inactivation as it spreads in cis across the chromosome. Here, we reveal a biophysical basis for its cis-limited diffusion. Xist RNA and HNRNPK together drive a liquid-liquid phase separation (LLPS) that encapsulates the chromosome.

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Inflammation-proliferation transition plays a key role in the successful healing of a common burn type, second-degree burn. Gynura procumbens in vitro adventitious root nanohydrogel is currently being studied for its immunomodulatory to improve reparative environment. Root production and nanohydrogel preparation was done respectively by in vitro propagation and emulsion/ solvent diffusion with carbomer as a polymer.

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As three-dimensional (3D) printing has emerged as a new manufacturing technology, the demand for high-performance 3D printable materials has increased to ensure broad applicability in various load-bearing structures. In particular, the thixotropic properties of materials, which allow them to flow under applied external forces but resist flowing otherwise, have been reported to enable rapid and high-resolution printing owing to their self-standing and easily processable characteristics. In this context, graphene nanosheets exhibit unique π-π stacking interactions between neighboring sheets, likely imparting self-standing capability to low-viscosity inks.

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Molecular-Scale Simulation of Wetting of Actin Filaments by Protein Droplets.

J Phys Chem B

January 2025

Department of Computer and Information Sciences, Department of Materials Science and Engineering, University of Delaware, Newark, Delaware 19716, United States.

Liquid phase-separating proteins can form condensates that play an important role in spatial and temporal organization of biological cells. The understanding of the mechanisms that lead to the formation of protein condensates and their interactions with other biomolecules may lead to processing routes for soft materials with tailored geometry and function. Fused in sarcoma (FUS) is an example of a nuclear protein that forms stable complexes, and recent studies have highlighted its ability to wet actin filaments and bundle them into networks.

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A Wenzel Interfaces Design for Homogeneous Solute Distribution Obtains Efficient and Stable Perovskite Solar Cells.

Adv Mater

January 2025

College of Chemistry and Chemical Engineering/Film Energy Chemistry for Jiangxi Provincial Key Laboratory (FEC), Nanchang University, 999 Xuefu Avenue, Nanchang, 330031, China.

The coffee-ring effect, caused by uneven deposition of colloidal particles in perovskite precursor solutions, leads to poor uniformity in perovskite films prepared through large-area printing. In this work, the surface of SnO is roughened to construct a Wenzel model, successfully achieving a super-hydrophilic interface. This modification significantly accelerates the spreading of the perovskite precursor solution, reducing the response delay time of perovskite colloidal particles during the printing process.

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