Direct synthesis of imidazothiones from simple, commercial substrates is not known. We report a method for the condensation of acetophenones, elemental sulfur, and ammonium acetate as a nitrogen source to obtain the hitherto challenging five-membered heterocycles. Functionalities such as halogen, trifluoromethyl, cyano, methylthio, and heteroaryl groups were well tolerated.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057481 | PMC |
| http://dx.doi.org/10.1039/d0ra03047c | DOI Listing |
Publication Analysis
Top Keywords
homo-condensation acetophenones
4
acetophenones imidazothiones
4
imidazothiones direct
4
direct synthesis
4
synthesis imidazothiones
4
imidazothiones simple
4
simple commercial
4
commercial substrates
4
substrates report
4
report method
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!