AI Article Synopsis
- A new method has been created to synthesize -3-alkenyl-2-amido-3-hydroxy esters from racemic α-amino-β-keto esters using an ATH/DKR protocol.
- This technique provides moderate to excellent yields and demonstrates high selectivity across various chemical characteristics for many different substrates.
- The methodology was successfully utilized in the asymmetric synthesis of the complex compound (+)-alexine, showcasing its versatility.
Article Abstract
A straightforward synthesis of -3-alkenyl-2-amido-3-hydroxy esters from the corresponding racemic α-amino-β-keto esters by using a ATH/DKR protocol has been developed. This method gives moderate to excellent yields with high chemo-, diastereo- and enantioselectivities for a broad range of substrates. In order to highlight the versatility of the methodology it was applied in an efficient asymmetric synthesis of the polyhydroxylated pyrrolizidine alkaloid (+)-alexine.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9059938 | PMC |
| http://dx.doi.org/10.1039/c9ra00173e | DOI Listing |
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