Novel hydroanthraquinones isolated from marine algal-derived endophytic fungus EN-501 exhibited promising antioxidant properties in preliminary studies, raising the prospect of adapting these compounds for therapeutic use in diseases caused by oxidative stress. For medicinal applications it is beneficial to develop a full understanding of the antioxidant activity of these compounds. In this study, the hydroperoxide radical scavenging activity of five natural hydroanthraquinones was evaluated by kinetic and thermodynamic calculations. The results showed that the radical scavenging of these hydroanthraquinones in the gas phase and in lipid solvents was defined by the formal hydrogen transfer mechanism, that for the polar environments was decided by the sequential proton loss electron transfer pathway. The hydroanthraquinones exhibited good hydroperoxide scavenging activity in both polar and non-polar media. The overall rate constant values for the radical scavenging reaction were in the range of 3.42 × 10 to 2.60 × 10 M s and 3.80 × 10 to 5.87 × 10 M s in pentyl ethanoate and water solvents, respectively. Thus the activity of 8-hydroxyconiothyrinone B (1) is about 2.6 and 444.6 times higher than that of Trolox in the studied solvents, identifying 8-hydroxyconiothyrinone B as a promising antioxidant.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054120PMC
http://dx.doi.org/10.1039/d0ra04013dDOI Listing

Publication Analysis

Top Keywords

radical scavenging
12
antioxidant activity
8
activity natural
8
natural hydroanthraquinones
8
promising antioxidant
8
scavenging activity
8
activity
5
hydroanthraquinones
5
thermodynamic kinetic
4
kinetic study
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!