AI Article Synopsis
- A new method is introduced for synthesizing 2-oxo-acetamidines from methyl ketones, using copper-catalyzed C(sp)-H amidination with aromatic amines and DMF as nitrogen sources.
- The process achieves yields ranging from 47% to 92% and efficiently forms both C-N and C=N bonds simultaneously.
- A possible mechanism for this reaction is proposed based on initial experiments.
Article Abstract
A convenient method for the synthesis of 2-oxo-acetamidines from methyl ketones using aromatic amines and DMF as nitrogen sources is reported copper-catalyzed C(sp)-H amidination. Various methyl ketones react readily with aromatic amines and DMF, producing 2-oxo-acetamidines in yields of 47 to 92%. This protocol features the simultaneous formation of C-N and C[double bond, length as m-dash]N bonds using DMF and aromatic amines as two different nitrogen sources. It thus provides an efficient approach to construct acyclic amidines three C(sp)-H bond amidination. Based on the preliminary experiments, a plausible mechanism of this transformation is disclosed.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9061129 | PMC |
| http://dx.doi.org/10.1039/c9ra00616h | DOI Listing |
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