Background: The field of medicine is rapidly becoming digitised, and in the process passively amassing large volumes of healthcare data. Machine learning and data analytics are advancing rapidly, but these have been slow to be taken up in the day-to-day delivery of healthcare. We present an application of machine learning to optimise a laboratory testing programme as an example of benefiting from these tools.
Methods: Canterbury District Health Board has recently implemented a system for urgent lab sample processing in the community, reducing unnecessary emergency presentations to hospital. Samples are transported from primary care facilities to a central laboratory. To improve the efficiency of this service, our team built a prototype transport scheduling platform using machine learning techniques and simulated the efficiency and cost impact of the platform using historical data.
Results: Our simulation demonstrated procedural efficiency and potential for annual savings between 5% and 14% from implementing a real-time lab sample transport scheduling platform. Advantages included providing a forward job list to the laboratory, an expected time to result and a streamlined transport request process.
Conclusion: There are a range of opportunities in healthcare to use large datasets for improved delivery of care. We have described an applied example of using machine learning techniques to improve the efficiency of community patient lab sample processing at scale. This is with a view to demonstrating practical avenues for collaboration between clinicians and machine learning engineers.
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http://dx.doi.org/10.1136/bmjstel-2017-000289 | DOI Listing |
Sci Rep
January 2025
DIAPath, Center for Microscopy and Molecular Imaging (CMMI), Université Libre de Bruxelles (ULB), 6041, Gosselies, Belgium.
Over the past decade, neuropathological diagnosis has undergone significant changes, integrating morphological features with molecular biomarkers. The molecular era has successfully refined neuropathological diagnostic accuracy; however, a substantial number of CNS tumor diagnoses remain challenging, particularly in children. DNA methylation classification has emerged as a powerful machine learning approach for clinical decision-making in CNS tumors.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Gynecology & Obstetrics, Qilu Hospital of Shandong University, Jinan, China.
Endometriosis (EM) is a chronic disease that can cause pain and infertility in patients. As is well known, immune cell infiltrations (ICIs) play important roles in the pathogenesis of EM. However, the pathogenesis and biomarkers of EM that can be used in clinical practice and their relationship with ICIs still need to be elucidated.
View Article and Find Full Text PDFNano Converg
January 2025
Department of Electrical and Computer Engineering, National University of Singapore (NUS), Singapore, 117576, Singapore.
Ferroelectric capacitive memories (FCMs) utilize ferroelectric polarization to modulate device capacitance for data storage, providing a new technological pathway to achieve two-terminal non-destructive-read ferroelectric memory. In contrast to the conventional resistive memories, the unique capacitive operation mechanism of FCMs transfers the memory reading and in-memory computing to charge domain, offering ultra-high energy efficiency, better compatibility to large-scale array, and negligible read disturbance. In recent years, extensive research has been conducted on FCMs.
View Article and Find Full Text PDFPharm Res
January 2025
Department of Pharmacy, Jinshan Hospital Affiliated to Fudan University, Shanghai, China.
Objective: This study aimed to establish an optimal model based on machine learning (ML) to predict Valproic acid (VPA) trough concentrations in Chinese adult epilepsy patients.
Methods: A single-center retrospective study was carried out at the Jinshan Hospital affiliated with Fudan University from January 2022 to December 2023. A total of 102 VPA trough concentrations were split into a derivation cohort and a validation cohort at a ratio of 8:2.
Commun Psychol
January 2025
Department of Psychology, Queens University, Kingston, Ontario, Canada.
Psychological states influence our happiness and productivity; however, estimates of their impact have historically been assumed to be limited by the accuracy with which introspection can quantify them. Over the last two decades, studies have shown that introspective descriptions of psychological states correlate with objective indicators of cognition, including task performance and metrics of brain function, using techniques like functional magnetic resonance imaging (fMRI). Such evidence suggests it may be possible to quantify the mapping between self-reports of experience and objective representations of those states (e.
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