Middle East respiratory syndrome coronavirus (MERS-CoV) poses a serious threat to human health, and currently there are no effective or specific therapies available to treat it. Herein a series of 1-phenyl--(benzothiazol-2-yl)methanimine derivatives with inhibitory activity against MERS-CoV are described. The compound 4f with a 50% inhibition concentration value of 0.09 μM is a promising inhibitor that warrants further evaluation, towards the development of potential anti-MERS-CoV drugs.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9058255 | PMC |
| http://dx.doi.org/10.1039/d0ra08442e | DOI Listing |
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