AI Article Synopsis
- - The study focused on isolating a substance called α-d-(1→6)-glucan from banana pulp, which showed strong effects on immune function.
- - This glucan significantly enhanced important immune activities, including the production of nitric oxide and various cytokines, while also increasing the expression of specific genes in macrophage cells.
- - The findings suggest that α-d-(1→6)-glucan activates key signaling pathways (NF-κB and MAPK), indicating its potential role as a beneficial component of bananas for health.
Article Abstract
Banana is a delicious fruit with potent immunomodulatory function. In this study, α-d-(1→6)-glucan was purified from banana pulp. It could significantly promote pinocytic activity and production of nitric oxide (NO), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α). The mRNA expression of nitric oxide synthase (iNOS), IL-6 and TNF-α was increased in RAW264.7 macrophages. α-d-(1→6)-glucan could not only increase the expression levels of p-p65 and p-IκBα, but also induce the translocation of nuclear factor-kappa B (NF-κB) p65 into the nucleus. Moreover, mitogen-activated protein kinases (MAPKs), including p-ERK, p-JNK and p-p38, were upregulated. These results suggested that NF-κB and MAPK signaling pathways were involved in the immunomodulatory mechanisms of α-d-(1→6)-glucan. The results revealed that α-d-(1→6)-glucan might be the critical component responsible for the health benefits of banana.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9061079 | PMC |
| http://dx.doi.org/10.1039/c9ra00113a | DOI Listing |
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