AI Article Synopsis
- Electrophilic fluorine-mediated reactions were used to create various fluoro-substituted spiro-isoxazoline ethers and lactones.
- Compounds 4d and 4n demonstrated significant anti-viral activity against human cytomegalovirus, whereas compounds 4l and 5f showed strong cytotoxic effects on certain cancer cell lines.
- The success of these compounds highlights their potential for further development in drug discovery as new anti-viral and anti-cancer treatments.
Article Abstract
Electrophilic fluorine-mediated dearomative spirocyclization has been developed to synthesize a range of fluoro-substituted spiro-isoxazoline ethers and lactones. The biological assays of synthesized compounds were probed for anti-viral activity against human cytomegalovirus (HCMV) and cytotoxicity against glioblastomas (GBM6) and triple negative breast cancer (MDA MB 231). Interestingly, compounds 4d and 4n showed significant activity against HCMV (IC ∼ 10 μM), while 4l and 5f revealed the highest cytotoxicity with IC = 36 to 80 μM. The synthetic efficacy and biological relevance offer an opportunity to further drug-discovery development of fluoro-spiro-isoxazolines as novel anti-viral and anti-cancer agents.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056317 | PMC |
| http://dx.doi.org/10.1039/d0ra06148d | DOI Listing |
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