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production of pederin by labrenzin pathway expansion. | LitMetric

production of pederin by labrenzin pathway expansion.

Metab Eng Commun

Department of Microbial and Plant Biotechnology, Centro de Investigaciones Biológicas, Agencia Estatal Consejo Superior de Investigaciones Científicas, Madrid, Spain.

Published: June 2022

AI Article Synopsis

Article Abstract

Pederin is a potent polyketide toxin that causes severe skin lesions in humans after contact with insects of genus Due to its potent anticancer activities, pederin family compounds have raised the interest of pharmaceutical industry. Despite the extensive studies on the cluster of biosynthetic genes responsible for the production of pederin, it has not yet been possible to isolate and cultivate its bacterial endosymbiont producer. However, the marine bacterium sp. PHM005 was recently reported to produce labrenzin, the closest pederin analog. By cloning a synthetic gene encoding one of the three -methyltraferase of the pederin cluster into sp. PHM005 we have been able to produce pederin for the first time by fermentation in the new recombinant strain.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062313PMC
http://dx.doi.org/10.1016/j.mec.2022.e00198DOI Listing

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