A novel imidazo[1,5-]pyridine-hemicyanine based ratiometric fluorescent probe for detection of mitochondrial SO was designed and synthesized. The probe is based on a fluorescence resonance energy transfer (FRET) mechanism. It exhibits high selectivity and sensitivity towards SO with a fast response time (3 min) and detection limit of 0.13 μM. Further, it showed low cytotoxicity and was successfully applied to image exogenous mitochondrial SO in cells.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062019 | PMC |
| http://dx.doi.org/10.1039/c8ra10328c | DOI Listing |
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