AI Article Synopsis
- An ultra-sensitive MR imaging contrast agent was developed using FeO nanoparticles combined with Gd ions, achieving a uniform particle size of 100 nm.
- The coordination with Gd ions significantly improved the contrast agent's transverse relaxivity from 131.89 mM s to 202.06 mM s, indicating enhanced imaging capabilities.
- Testing on hepatoma cells and rat livers demonstrated the nanoparticles' low cytotoxicity and effectiveness for MR diagnosis.
Article Abstract
An ultra-sensitive -weighted MR imaging contrast agent was prepared based on FeO nanoparticles and Gd ions (FeO@Gd). Amino modified FeO nanoparticles were conjugated to diethylenetriamine pentaacetic acid, and finally coordinated with Gd ions. The nanoparticles had a uniform morphology with a size of 100 nm and a Gd/Fe mass ratio of 1/110. The (transverse relaxivity) of the FeO nanoparticles increased from 131.89 mM s to 202.06 mM s after coordination with Gd ions. MR measurements showed that the aqueous dispersion of FeO@Gd nanoparticles had an obvious concentration-dependent negative contrast enhancement. Hepatoma cells were selected to test the cytotoxicity and MR imaging effect. The application of FeO@Gd nanoparticles as contrast agents was also exploited for -weighted MR imaging of rat livers. All the results showed the effectiveness of the nanoparticles in MR diagnosis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9053615 | PMC |
| http://dx.doi.org/10.1039/d0ra01807d | DOI Listing |
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