A Ni(ii)-bis(oxazoline) complex and -TSOH are used to form enantioenriched 4-chromenes from -quinone methides (-QMs) and dicarbonyls, providing the desired products in up to 95% ee. The method is compatible with various β-ketoester substrates, and the products obtained could be converted into biologically active 4-chromene derivatives.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9058437 | PMC |
| http://dx.doi.org/10.1039/d0ra08906k | DOI Listing |
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