The light-induced antibacterial and antifungal properties of A[MIL] with M = Mo and W, A = organic cation, L = ligand have been studied. The photoactive compounds (TBA)[WI(CHSO)] and (TBA)[WI(COOCF)] have been incorporated into a permeable silicone matrix and were measured for their application in the decomposition of multi-resistant bioactive species (hospital germs) such as and as well as fungi. In addition, we present a new high volume synthesis route for these types of cluster compounds departing from the soluble compound WI.
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http://dx.doi.org/10.1039/d0ra04280c | DOI Listing |
Chem Sci
December 2024
Institut de Quimica Computacional i Catàlisi (IQCC) and Departament de Química, Universitat de Girona M. Aurèlia Capmany, 69 17003 Girona Catalonia Spain
Photodynamic therapy is an important tool in modern medicine due to its effectiveness, safety, and the ability to provide targeted treatment for a range of diseases. Photodynamic therapy utilizes photosensitizers to generate reactive oxygen species (ROS). Fullerenes can be used as photosensitizers to produce ROS in high quantum yields.
View Article and Find Full Text PDFInt J Nanomedicine
January 2025
State Key Laboratory of Pathogenesis Prevention and Treatment of High Incidence Diseases in Central Asia, School of Medical Engineering and Technology Xinjiang Medical University, Urumqi, 830011, People's Republic of China.
Purpose: A synergistic treatment strategy of phototherapy and chemotherapy has been shown to improve efficacy and offer unique advantages over monotherapy. The purpose of this study is to explore a new nanocarrier system with liposome as the inner membrane and erythrocyte membrane as the outer membrane, which aims to realize the leak-free load of phototherapy drug indocyanine green (ICG) and chemotherapy drug doxorubicin (DOX), prolong the circulation time in vivo and improve the therapeutic effect.
Patients And Methods: In this study, bilayer membrane-loaded ICG and DOX nanoparticles (RBC@ICG-DOX NPs) were prepared and characterized.
Turk J Pharm Sci
January 2025
University of Tlemcen, Faculty of Science, Department of Chemistry, Laboratory of Natural and Bioactive Substances, Tlemcen, Algeria.
Objectives: This study focused on the phytochemical, insecticidal, and bactericidal activities of Vahl, as well as molecular docking analysis of an acetylcholinesterase (AChE) inhibitor as a promising natural insecticide.
Materials And Methods: The leaves of were successively extracted with n-hexane, acetone, and methanol. Silica gel column chromatography of the methanol extract yielded compound 1.
Acta Biomater
January 2025
Shanghai Frontiers Science Center of Drug Target Identification and Delivery, National Key Laboratory of Innovative Immunotherapy, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai 200240, China. Electronic address:
Glioblastoma (GBM) persists as a highly fatal malignancy, with current clinical treatments showing minimal progress over years. Interstitial photodynamic therapy (iPDT) holds promise due to its minimally invasive nature and low toxicity but is impeded by poor photosensitizer penetration and inadequate GBM targeting. Here, we developed a biomimetic pure-drug nanomedicine (MM@CT), which co-assembles the photosensitizer chlorin e6 (Ce6) and the first-line chemotherapeutic drug (temozolomide, TMZ) for GBM, then camouflaged with macrophage membranes.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
Key Laboratory of Cold Chain Logistics Technology for Agro-Product, Ministry of Agriculture and Rural Affairs/Institute of Agro-Product Processing and Nuclear Agricultural Technology, Hubei Academy of Agricultural Sciences, Wuhan 430064, China; Hubei Engineering Research Center for Agro-Product Irradiation, Agro-product Processing Research Sub-center of Hubei Innovation Center of Agriculture Science and Technology, Wuhan 430064, China; Department of Materials Science and Technology, Nanjing University of Aeronautics & Astronautics, Nanjing 210016, China. Electronic address:
The development of biomass material is an important approach to alleviating the excessive using of plastic packaging, by which the product could be more environmentally friendly and lower toxicity. In this study, we developed a biodegradable photodynamic antibacterial food packaging film using nitrogen-doped carbon quantum dots (N-CQDs) synthesized from crayfish shells, combined with konjac glucomannan (KGM) and sodium alginate (SA). Casting method was used to prepare the composite film and results indicated that incorporation of N-CQDs significantly enhanced the mechanical and barrier properties of the film by reducing the number of micropores.
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