A new strategy for synthesizing silver doped mesoporous bioactive glass fibers and their bioactivity, antibacterial activity and drug loading performance.

A new strategy for preparing mesoporous metal-doped bioactive glass fibers (MBGFs) was designed, which included electrospinning and sulfonating mesoporous PS fibers, precipitating metal ions and bioactive glass sol-gel precursor into the mesoporous polystyrene (PS) fibers and calcinations. Silver-doped mesoporous BGFs (Ag-MBGFs) with a uniform diameter of 1-2 μm and a specific surface area of 40.22 m g were prepared as an example and characterized by SEM, XRD, TG, ICP and FTIR. These Ag-MBGFs showed excellent bioactivity, antibacterial properties and drug loading and release performance due to their special mesoporous and fibrous structure. The concentration of decreased from 1 × 10 colony-forming units per mL (CFU mL) to 2.5 × 10 CFU mL in 2 h and then to 2 × 10 CFU mL in 12 h when the concentration of the Ag-MBGFs reached 16 mg mL. BGFs of different compositions and functions could be prepared by the same strategy in a mesoporous PS fiber template, which could enrich materials for constructing orthopedic implants.