A mild and efficient enantioselective amination of 4-alkylisoquinoline-1,3(2,4)-dione derivatives was established, which is compatible with a broad range of substrates and delivers the final products in excellent yields (up to 99%) and ee values (up to 99%) with low catalyst loading (down to 1 mol%). The synthetic potential of this methodology was also demonstrated in the gram scale level.
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| http://dx.doi.org/10.1039/d0ra07806a | DOI Listing |
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