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[Emergence of a multidrug-resistant tuberculosis through inadequate treatment of isoniazid monoresistance].
Dtsch Med Wochenschr
October 2024
Pneumologie, Klinikum Würzburg-Mitte gGmbH, Standort Missioklinik, Würzburg, Deutschland.
History: We admitted a 65-year-old patient with suspected reactivation of a pulmonary tuberculosis for further diagnosis.
Findings And Diagnosis: 14 months after completing a standard treatment course against pulmonary tuberculosis, the patient presented with cough and night sweat. A CT-scan revealed signs of a bipulmonary progress.
Critical assessment of infants born to mothers with drug resistant tuberculosis.
EClinicalMedicine
October 2024
WHO Collaborating Centre for Tuberculosis, Sydney Infectious Diseases Institute, University of Sydney, Sydney, NSW, Australia.
Background: There have been no detailed descriptions of infants born to mothers treated for drug resistant TB in pregnancy. Critical case history assessment is important to identify risks and guide clinical practice.
Methods: In a cohort of pregnant women with multidrug or rifampicin resistant (MDR/RR)-TB enrolled between 1 January 2013 and 31 December 2022, we followed mother-infant pairs until the infant was 12 months old.
Silico-tuberculosis: An updated review.
Indian J Tuberc
October 2024
Department of Microbiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India; Viral Research and Diagnostic Laboratory, Department of Virology, Rajendra Memorial Research Institute of Medical Sciences (RMRIMS), Patna, Bihar, India. Electronic address:
Silico-Tuberculosis (silico-TB) is a severe combination of tuberculosis and silicosis, caused by occupational exposure to fine crystalline silica dust, which has become a global health concern. This comprehensive review compiles the updated knowledge regarding pathophysiology, clinical manifestations, important diagnostic techniques, treatment aspects, and challenges in understanding silico-TB. The review compiles the disease's history and epidemiology, highlighting a lack of data owing to poor monitoring and healthcare particularly in low- and middle-income countries like India.
View Article and Find Full Text PDFAntibiotic-loaded lactoferrin nanoparticles as a platform for enhanced infection therapy through targeted elimination of intracellular bacteria.
Asian J Pharm Sci
August 2024
NMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening & Guangdong-Hongkong-Macao Joint Laboratory for New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
Intracellular bacteria can multiply inside host cells and manipulate their biology, and the efficacy of traditional antibiotic drug therapy for intracellular bacteria is limited by inadequate drug accumulation. Fighting against these stealthy bacteria has been a long-standing challenge. Here, a system of stimuli-responsive lactoferrin (Lf) nanoparticles is prepared using protein self-assembly technology to deliver broad-spectrum antibiotic rifampicin (Rif) (Rif@Lf NPs) for enhanced infection therapy through targeted elimination of intracellular bacteria.
View Article and Find Full Text PDFBurden of drug-resistant tuberculosis by the GeneXpert MTB/RIF assay and its clinico-epidemiological aspects at a tertiary care hospital in West Bengal.
Indian J Med Microbiol
September 2024
Microbiology Department, Institute of Postgraduate Medical Education and Research, 244 A.J.C.Bose Road, Kolkata, 700020, India.
Multidrug -resistant tuberculosis (MDRTB) is a serious threat to mankind. India has the highest number of MDRTB cases, although majority remain undiagnosed due to inadequate diagnostic infrastructure, leading to increased community transmission and mortality. This one-year observational retrospective study highlighted the effectiveness of the National Tuberculosis Elimination Program (NTEP) for prompt detection of drug-resistant TB by GeneXpert MTB/RIF assay and revealed its associated clinico-epidemiological factors.
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