AI Article Synopsis
- This study focused on creating a patch made of cellulose/β-cyclodextrin that can noninvasively monitor glucose levels in interstitial fluid using a technique called reverse iontophoresis.
- The sensor demonstrated excellent performance with a high diffusion coefficient, strong linear correlation, and a sensitivity that remained unaffected by common interfering substances at physiological levels.
- The findings suggest that this innovative epidermal sensing approach could be a promising tool for continuous glucose monitoring in diabetes management.
Article Abstract
In this study, we aimed to develop a cellulose/β-cyclodextrin (β-CD) electrospun immobilized GOx enzyme patch with reverse iontophoresis for noninvasive monitoring of interstitial fluid (ISF) glucose levels (0.1-0.6 mM dm). analysis, performed using a sensor attached to flexible substrates, revealed that the high diffusion coefficient (9.0 × 10 cm s), the linear correlation coefficient ( = 0.998), the detection limit (9.35 × 10 M), and the linear range sensitivity (0-1 mM) of the sensor (5.08 μA mM) remained unaffected by the presence of interfering substances (, fructose, sucrose, uric acid, and acetaminophen) at physiological levels. The present results indicate that the new epidermal sensing strategy using nanofibers for continuous glucose monitoring has potential to be applied in diagnosis of diabetes.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9067108 | PMC |
| http://dx.doi.org/10.1039/c9ra03887f | DOI Listing |
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