Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Zagreb, Croatia.
Published: December 2022
AI Article Synopsis
Article Abstract
As a result of our previous research focussed on benzimidazoles, herein we present design, synthesis, QSAR analysis and biological activity of novel N-substituted benzimidazole derived carboxamides. Carboxamides were designed to study the influence of the number of methoxy groups, the type of the substituent placed at the benzimidazole core on biological activity. Pronounced antioxidative activity displayed unsubstituted (IC ≈ 3.78 mM, 538.81 mmolFe/mmolC) and dimethoxy substituted derivative (IC ≈ 5.68 mM, 618.10 mmolFe/mmolC). Trimethoxy substituted and unsubstituted compound with isobutyl side chain at N atom showed strong activity against HCT116 (IC ≈ 0.6 µM, both) and H 460 cells (IC ≈ 2.5 µM; 0.4 µM), being less cytotoxic towards non-tumour cell. Antioxidative activity in cell generally confirmed relatively modest antioxidant capacity obtained in DPPH/FRAP assays of derivatives and . The 3D-QSAR models were generated to explore molecular properties that have the highest influence on antioxidative activity.
Herbs rich in secondary metabolites may possess beneficial properties in livestock nutrition and health. 49 Polygonaceae species of European mountain regions were included in a qualitative systematic review based on the methodological framework of the PRISMA statement. 174 relevant publications were identified.
South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Key Laboratory of South China Sea Fishery Resources Exploitation and Utilization, Ministry of Agriculture and Rural Affairs, Guangzhou, China.
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State Key Laboratory of Biocontrol, Guangdong Provincial Key Laboratory for Aquatic Economic Animals and Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), School of Life Sciences, Sun Yat-sen University, Guangzhou, China.
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Spinal cord ischemia/reperfusion (IR) injury (SCII) can cause major autonomic, sensory, and motor damage and loss. The upregulation of Nrf2, a primary orchestrator of the oxidative stress response, has beneficial effects in SCII. Here, we aimed to uncover a SCII-related transcription factor that is able to elevate Nrf2 expression.
When processing lucuma (), waste such as shells and seeds is generated, which is a source of bioactive compounds. Recently, lucuma seed (LS), especially its oily fraction, has been studied for containing phytosterols and tocopherols, powerful antioxidants with health benefits. This study proposes lucuma seed oil (LSO) extraction using supercritical fluid (SCF) to improve the quality of the extract and minimize the environmental impact.
