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| http://dx.doi.org/10.23938/ASSN.0992 | DOI Listing |
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[Progress in multiomics research on high altitude polycythemia].
Zhonghua Xue Ye Xue Za Zhi
August 2024
Department of Hematology, Qinghai Provincial People's Hospital, Xining 810007, China.
Chronic mountain sickness (CMS) or Monge syndrome is a disease that is prevalent at altitude above 2 500 meters. High altitude polycythemia (HAPC) is one subtype of CMS. EPAS1 and EGNL1 are the most critical high-altitude adaptation genes in the genome of the Tibetan population.
View Article and Find Full Text PDFAdvancements in understanding the role of ferroptosis in hypoxia-associated brain injury: a narrative review.
Transl Pediatr
June 2024
Department of Geriatric Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Background And Objective: Ferroptosis, a form of programmed cell death driven by lipid peroxidation and dependent on iron ions, unfolds through a sophisticated interplay of multiple biological processes. These include perturbations in iron metabolism, lipid peroxidation, aberrant amino acid metabolism, disruptions in hypoxia-inducible factor-prolyl hydroxylase (HIF-PHD) axis, and endoplasmic reticulum (ER) stress. Recent studies indicate that ferroptosis may serve as a promising therapeutic target for hypoxia-associated brain injury such as hypoxic-ischemic brain damage (HIBD) and cerebral ischemia-reperfusion injury (CIRI).
View Article and Find Full Text PDFRoxadustat (FG-4592) abated lipopolysaccharides-induced depressive-like symptoms PI3K signaling.
Front Mol Neurosci
March 2023
College of Forensic Medicine, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China.
Background: Despite its role in inflammation and the redox system under hypoxia, the effects and molecular mechanisms of hypoxia-inducible factor (HIF) in neuroinflammation-associated depression are poorly explored. Furthermore, Prolyl hydroxylase domain-containing proteins (PHDs) regulate HIF-1; however, whether and how PHDs regulate depressive-like behaviors under Lipopolysaccharides (LPS)-induced stress conditions remain covered.
Methods: To highlight the roles and underlying mechanisms of PHDs-HIF-1 in depression, we employed behavioral, pharmacological, and biochemical analyses using the LPS-induced depression model.
Roxadustat, a HIF-PHD inhibitor with exploitable potential on diabetes-related complications.
Front Pharmacol
February 2023
Department of Pathophysiology, College of Basic Medical Science, China Medical University, Shenyang, Liaoning, China.
Diabetes mellitus (DM) is a group of metabolic diseases caused by absolute or relative deficiency of insulin secretion and characterized by chronic hyperglycemia. Its complications affect almost every tissue of the body, usually leading to blindness, renal failure, amputation, etc. and in the final stage, it mostly develops into cardiac failure, which is the main reason why diabetes mellitus manifests itself as a high clinical lethality.
View Article and Find Full Text PDF[Role of HIF-PHD inhibitor in improving adherence and safety in the treatment of anemia in chronic kidney disease].
An Sist Sanit Navar
April 2022
Servicio de Nefrología. Clínica Universidad de Navarra. Pamplona. España..
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