Manganese (Mn) poisoning can happen in the case of environmental pollution and occupational exposure. However, the underlying mechanisms of Mn-induced teste toxicity and whether mitochondrion and heat shock proteins (HSPs) are involved in toxic effect of Mn on chicken testes remain poorly understood. To investigate this, MnCl·4HO was administered in the diet (600, 900, and 1800 mg/kg Mn) of chickens for 30, 60, and 90 days. Electron microscopy and qPCR were performed. Results showed that Mn exposure suppressed dose- and time-dependently HSP40 and HSP60 mRNA levels, meanwhile increased does-dependently HSP27, HSP70, and HSP90 mRNA levels at all three time points under three Mn exposure concentrations. Furthermore, Mn treatment damaged myoid cells, spermatocytes, and Sertoli cells through electron microscopic observation, indicating that Mn treatment damaged chicken testes. In addition, abnormal shapes of mitochondria were found, and mitochondria displayed extensive vacuolation. The increase of HSP90 and HSP70 induced by Mn exposure inhibited HSP40 and stimulated HSP27, respectively, in chicken testes, which needs further to be explored. Taken together, our study suggested that there was toxic effect in excess Mn on chickens, and HSPs and mitochondria were involved in the mechanism of dose-dependent injury caused by Mn in chicken testes. This study provided new insights for Mn toxicity identification in animal husbandry production practice.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s12011-022-03259-7 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Sperm production, gonadal oxidative stress, DNA damage biomarkers and reproductive hormonal responses of cocks fed AFB1-contaminated diets supplemented with wireweed leaf.
Trop Anim Health Prod
December 2024
Animal Nutrition Laboratory, Department of Animal Production and Health, School of Agriculture and Agricultural Technology, The Federal University of Technology Akure, P.M.B. 704, Akure, Nigeria.
To assess the ameliorative effects of wireweed leaf supplement (WLS) and ascorbate on reproductive potentials and gonadal oxidative status of cocks fed aflatoxin B1 (AFB1) contaminated diets, a total of 250 sexually mature cocks were distributed into five treatment groups: 1 (Control/Basal diet), 2 (Basal + 1 mg/kg AFB1), 3 (Basal + 1 mg/kg AFB1 + 200 mg/kg Ascorbate), 4 (Basal + 1 mg/kg AFB1 + 2.50 g/kg WLS) and 5 (Basal + 1 mg/kg AFB1 + 5.00 g/kg WLS).
View Article and Find Full Text PDFEffects of caponization and age on the histology, lipid localization and fibre diameter in muscles of Rhode Island Red cockerels.
Pol J Vet Sci
December 2024
Department of Animal Welfare and Research, University of Warmia and Mazury in Olsztyn, Oczapowskiego 5, Poland.
Poultry scientists are constantly studying different breeds of cockerels that would be suitable for capon meat production. Capon meat, although not yet very popular, is characterized by exceptional taste qualities that could appeal to many customers. Obtaining the appropriate palatability, structure and tenderness of capon meat is possible thanks to the reduction in androgen levels following the castration of roosters.
View Article and Find Full Text PDFImpact of comb type on production performance, egg production quality, reproductive performance, and blood biochemical indexes in Tianfu chickens.
Poult Sci
November 2024
State Key Laboratory of Swine and Poultry Breeding Industry, Sichuan Agricultural University, Chengdu 611130, China; Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China; Key Laboratory of Livestock and Poultry Multi-omics, Ministry of Agriculture and Rural Affairs, College of Animal and Technology (Institute of Animal Genetics and Breeding), Sichuan Agricultural University, Chengdu 611130, China. Electronic address:
The comb, as a secondary sexual characteristic in chickens, serves as an important indicator of sexual maturity and potential reproductive. This study explored the relationship between comb types and production performance in Tianfu G01 chickens. Single-comb hens exhibited significantly lower laying rates compared to rose-comb hens during specific weeks (24-26, 27-28, 30, 32-34, and 38-43) but had higher average egg weights at 22, 23, 33, and 36-43 weeks.
View Article and Find Full Text PDFSodium toxicosis in chickens: case series (2014-2023) and literature review.
J Vet Diagn Invest
December 2024
California Animal Health & Food Safety Laboratory System, Turlock.
Article Synopsis
- In a recent study covering cases from 2014 to 2023, sodium toxicosis in chickens was linked to serious health issues and significant losses in the poultry industry, with a detailed analysis conducted on 7 affected cases.
- The autopsy findings revealed common lesions including fluid accumulation in various organs, respiratory and kidney issues, and significant differences in sodium levels in the brains of affected versus healthy chickens.
- Feed samples from sodium toxicosis cases showed sodium levels far exceeding the safe limit of 2,000 ppm, ranging from 2,500 to 12,000 ppm, indicating a possible cause for the toxicity observed in affected chickens.
Environmental adaptation and genetic insights: Cloning, bioinformatics, and tissue expression analysis of the LCORL gene in Guangxi Partridge Chicken.
Chemosphere
December 2024
College of Animal Science and Technology, Guangxi University, Nanning, 530004, China. Electronic address:
Article Synopsis
- The study focused on the structure and expression of the LCORL gene in the Guangxi partridge chicken, revealing its coding region is 1557 bp and encodes a protein with 518 amino acids.
- Sequence analysis found three non-synonymous and one synonymous mutation, with a high genetic similarity (99.7%) to the domestic chicken's LCORL gene.
- Further findings showed that LCORL expression is highest in the testis, indicating its potential role in rooster testis development and opening avenues for future research in poultry genetics and sustainable farming practices.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!