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The potential risk factors of postoperative cognitive dysfunction for endovascular therapy in acute ischemic stroke with general anesthesia.
Open Med (Wars)
December 2024
Department of Anesthesiology, Shanghai United Family Hospital, Shanghai 200050, China.
Background: Postoperative cognitive dysfunction (POCD) frequently occurs following endovascular therapy for acute ischemic stroke (AIS). Given the complexity of predicting AIS clinically, there is a pressing need to develop a preemptive prediction model and investigate the impact of anesthesia depth on AIS.
Methods: A total of 333 patients diagnosed with AIS were included in the study, comprising individuals with non-POCD ( = 232) or POCD ( = 101).
Assessing severity of pediatric pneumonia using multimodal transformers with multi-task learning.
Digit Health
December 2024
Department of Data and Information, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Objective: While current multimodal approaches in the diagnosis and severity assessment of pneumonia demonstrate remarkable performance, they frequently overlook the issue of modality absence-a common challenge in clinical practice. Thus, we present the (RMT) model, crafted to bridge this gap. The RMT model aims to enhance diagnosis and severity assessment accuracy in situations with incomplete data, thereby ensuring it meets the complex needs of real-world clinical settings.
View Article and Find Full Text PDFComparative analysis of stomatal pore instance segmentation: Mask R-CNN vs. YOLOv8 on Phenomics Stomatal dataset.
Front Plant Sci
December 2024
Department of Plant Resources and Environment, Jeju National University, Jeju, Republic of Korea.
This study conducts a rigorous comparative analysis between two cutting-edge instance segmentation methods, Mask R-CNN and YOLOv8, focusing on stomata pore analysis. A novel dataset specifically tailored for stomata pore instance segmentation, named PhenomicsStomata, was introduced. This dataset posed challenges such as low resolution and image imperfections, prompting the application of advanced preprocessing techniques, including image enhancement using the Lucy-Richardson Algorithm.
View Article and Find Full Text PDFFused extracellular vesicles from M macrophages and human umbilical cord mesenchymal stem cells for the targeted regulation of macrophage pyroptosis in periprosthetic osteolysis.
J Extracell Vesicles
December 2024
Department of Orthopedics, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
The development of strategies for the prevention and treatment of aseptic loosening of prostheses stands as a critical area of global research interest. The pyroptosis of local macrophages triggered by wear particles plays a pivotal role in the onset of periprosthetic osteolysis and subsequent loosening. Extracellular vesicles, carrying the surface components and regulatory molecules of their parent cells, embody the cellular characteristics and biological functions of these progenitors.
View Article and Find Full Text PDFTough Polyurethane Hydrogels with a Multiple Hydrogen-Bond Interlocked Bicontinuous Phase Structure Prepared by In Situ Water-Induced Microphase Separation.
Adv Mater
December 2024
Engineering Research Center of Energy Storage Materials and Devices Ministry of Education, School of Chemistry, Xi'an Jiaotong University, Xi'an, 710049, China.
Hydrogels with mechanical performances similar to load-bearing tissues are in demand for in vivo applications. In this work, inspired by the self-assembly behavior of amphiphilic polymers, polyurethane-based tough hydrogels with a multiple hydrogen-bond interlocked bicontinuous phase structure through in situ water-induced microphase separation strategy are developed, in which poly(ethylene glycol)-based polyurethane (PEG-PU, hydrophilic) and poly(ε-caprolactone)-based polyurethane (PCL-PU, hydrophobic) are blended to form dry films followed by water swelling. A multiple hydrogen bonding factor, imidazolidinyl urea, is introduced into the synthesis of the two polyurethanes, and the formation of multiple hydrogen bonds between PEG-PU and PCL-PU can promote homogeneous microphase separation for the construction of bicontinuous phase structures in the hydrogel network, by which the hydrogel features break strength of 12.
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