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Long-chain chlorinated paraffins (LCCPs) exposure causes senescence and inflammatory damage in cardiomyocytes.
J Environ Manage
January 2025
College of Animal Science and Technology, Jilin Agricultural University, Changchun, 130118, China. Electronic address:
Humans can be exposed to LCCPs through air and diet, leading to their accumulation in the body. Given the significance of understanding potential health risks, a thorough investigation into the detrimental health impacts of LCCPs is paramount. In this study, we conducted a series of experiments to investigate the effects of LCCPs on cardiomyocytes, employing techniques such as flow cytometry, western-blot, indirect immunofluorescence, and confocal microscopy.
View Article and Find Full Text PDFInvestigating polychlorinated alkanes in technical chlorinated paraffin mixtures and polymer products available in Vietnam.
Chemosphere
January 2025
Faculty of Chemistry, University of Science, Vietnam National University, Hanoi, 19 Le Thanh Tong, Hanoi, 10000, Viet Nam. Electronic address:
Chlorinated paraffins (CPs) are chemical additives mostly composed of polychlorinated alkanes (PCAs) which may impact on the environment and human health; however, little is known about their presence in Southeast Asia. To fill this knowledge gap, we assessed 74 PCA homolog groups commonly referred to as short-chain (SCCPs: PCAs-C), medium-chain (MCCPs: PCAs-C), and long-chain CPs (LCCPs: PCAs-C) in technical CP mixtures (n = 4) and polymer samples (n = 49), including recycled plastics, collected in Vietnam in 2023. The contents of measured PCA homolog groups in technical CP mixtures were 86,000-930,000 mg/kg for PCAs-C; 85,000-990,000 mg/kg for PCAs-C; and 23,000-180,000 mg/kg for PCAs-C.
View Article and Find Full Text PDFPlanar solid phase extraction for chlorinated paraffin analysis - irradiation chamber for standardized derivatization on planar thin-layers.
J Chromatogr A
January 2025
Institute of Food Chemistry, Department of Food Chemistry and Analytical Chemistry, University of Hohenheim, Garbenstraße 28, 70599 Stuttgart, Germany. Electronic address:
As an established analytical method, high-performance thin-layer chromatography (HPTLC) offers powerful capabilities. This study focused on its application to analyze chlorinated paraffins (CP) by planar solid phase extraction (pSPE). Based on previous work, an irradiation chamber was developed to investigate the derivatization process on planar thin-layers and ensure a robust and reproducible analysis.
View Article and Find Full Text PDFAccumulation of chlorinated paraffins in adipocytes is determined by cellular lipid content and chlorination level.
Arch Toxicol
January 2025
Department of Biochemistry and Microbiology, University of Chemistry and Technology, Technická 3, 16000, Prague, Czech Republic.
Chlorinated paraffins (CPs) are environmental pollutants extensively used in industries. While the use of short-chain chlorinated paraffins (SCCPs) has been restricted since 2017, the use of medium-chain chlorinated paraffins (MCCPs) has risen as their replacement. Due to lipophilic character, it can be expected that CPs enter the cells; however, the in vitro accumulation potential of CPs remains poorly understood.
View Article and Find Full Text PDFOccurrence, Bioaccumulation, and Trophic Transfer of Short-Chain Chlorinated Paraffins (SCCPs) in a Marine Food Web from Laizhou Bay, Bohai Sea (Eastern China).
Toxics
November 2024
Shandong Provincial Key Laboratory of Restoration for Marine Ecology, Shandong Marine Resource and Environment Research Institute, Yantai 264006, China.
Short-chain chlorinated paraffins (SCCPs) are a persistent organic pollutant, and limited information is available on their bioaccumulation and trophic transfer, which would be affected by carbon chain length, chlorine content, and hydrophobicity. In this study, relevant data on SCCPs in water, sediments, and organisms collected from Laizhou Bay were analyzed to investigate the specific distribution of SCCPs and their bioaccumulation and trophic transfer. In water and sediments, the average SCCP concentrations (ΣSCCPs) were 362.
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