Chronic Consumption of Moringa Leaf Powder () Concentration-Dependent Effects in a Type 2 Diabetes Model.

Objective: The metabolic effects of chronic consumption of food laced with different doses of moringa leaf powder (MLP) were assessed using a heteroallelic mutant of the sole insulin receptor gene of (), and the () control stock.

Methods: The MLP composition was partially determined. Both strains were raised in a standard diet (SD) or in a SD supplemented with different MLP doses (0.5, 1.5, 2.5, 4.0, and 5.5%) until 4-5 days of emergence. Afterward, the total carbohydrate, lipid, glucose, and triacylglyceride levels were measured in the flies. Additionally, survival and weight changes were reported. For metabolic tests, female and male virgin flies were evaluated separately.

Results: Low MLP supplementation improved carbohydrate and glucose levels in the strain. Additionally, the mutant strain reported lower lipid content when subjected to the same regimes. Survival improved in both strains with low MLP doses, while chronic consumption of high MLP doses resulted in triacylglycerides increase, weight gain, and survival reduction.

Conclusion: Low doses of MLP supplementation improves some metabolic parameters that affect flies' survival, especially in the strain. Furthermore, the same low doses of MLP treatments also resulted in metabolic improvements in the -mutant flies; however, MLP consumption levels should be carefully assessed.

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