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Z-DNA binding protein 1 promotes heatstroke-induced cell death. | LitMetric

Z-DNA binding protein 1 promotes heatstroke-induced cell death.

Science

Department of Critical Care Medicine and Hematology, The 3rd Xiangya Hospital, Central South University, Changsha 410000, P.R. China.

Published: May 2022

AI Article Synopsis

  • * Research indicates that Z-DNA binding protein 1 (ZBP1) plays a crucial role in heatstroke by initiating cell death through a pathway involving receptor-interacting protein kinase 3 (RIPK3).
  • * Deleting components like ZBP1 and RIPK3 can reduce serious effects of heat stress, suggesting ZBP1 has an important role in how the body responds to extreme heat.

Article Abstract

Heatstroke is a heat stress-induced, life-threatening condition associated with circulatory failure and multiple organ dysfunctions. If global warming continues, heatstroke might become a more prominent cause of mortality worldwide, but its pathogenic mechanism is not well understood. We found that Z-DNA binding protein 1 (ZBP1), a Z-nucleic acid receptor, mediated heatstroke by triggering receptor-interacting protein kinase 3 (RIPK3)-dependent cell death. Heat stress increased the expression of ZBP1 through heat shock transcription factor 1 (HSF1) and activated ZBP1 through a mechanism independent of the nucleic acid sensing action. Deletion of ZBP1, RIPK3, or both mixed lineage kinase domain-like (MLKL) and caspase-8 decreased heat stress-induced circulatory failure, organ injury, and lethality. Thus, ZBP1 appears to have a second function that orchestrates host responses to heat stress.

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Source
http://dx.doi.org/10.1126/science.abg5251DOI Listing

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