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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9070914 | PMC |
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0268357 | PLOS |
Heliyon
January 2025
Department of Orthopedics, Beijing LongFu Hospital, Beijing, China.
Objective: We aimed to investigate the effects of Tongluo Zhitong formula on synovial fibroblast proliferation in human knee osteoarthritis (KOA).
Methods: Discarded synovial tissue collected from patients undergoing total knee arthroplasty at our hospital was digested with type I collagenase. Primary culture was performed on three to four generations of fibroblasts, which were treated with high, medium, and low concentrations of Tongluo Zhitong formula.
Blood Adv
January 2025
The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Cytoskeletal remodeling and mitochondrial bioenergetics play important roles in thrombocytopoiesis and platelet function. Recently, α-actinin-1 mutations have been reported in patients with congenital macrothrombocytopenia. However, the role and underlying mechanism of α-actinin-1 in thrombocytopoiesis and platelet function remain elusive.
View Article and Find Full Text PDFBiomed Pharmacother
January 2025
Department of Pathology, Affiliated Hospital of Jining Medical University, Jining, Shandong 272029, China. Electronic address:
CK-666, an inhibitor of the actin-related protein complex 2/3 (Arp2/3), can suppress lamellipodia formation and cell migration. However, research on its application in tumor therapy is still limited. Using RNA-seq, we clustered and analyzed the functions of differentially expressed mRNAs in CK-666-treated tumor cells.
View Article and Find Full Text PDFRSC Adv
January 2025
Tianjin Key Laboratory for Modern Drug Delivery and High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University Weijin Road Tianjin 300072 China +86-22-87401895 +86-22-87401895.
[This retracts the article DOI: 10.1039/C8RA07163B.].
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
School of Basic Medical Sciences, Kunming Medical University, Kunming 650500, Yunnan, China. Electronic address:
Most Kunitz inhibitors exhibit serine protease inhibitory activity, but limited information is available on the regulation of platelet function. Herein, we report the purification and characterization of a novel single Kunitz domain inhibitor (Sibanin) from the salivary glands of the black fly Simulium bannaense. Recombinant Sibanin prolonged activated partial thromboplastin time and prothrombin time, and exhibited high-affinity binding to FXa and elastase with a KD of 5.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!