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Low-Grade Non-intestinal Type Sinonasal Adenocarcinoma: A Case Report.
Cureus
October 2024
Otolaryngology and Head and Neck Surgery, King Faisal Specialist Hospital and Research Center, Riyadh, SAU.
Sinonasal non-intestinal-type adenocarcinomas represent a rare subset of head and neck cancers with distinct pathological and clinical characteristics. Patients usually present with nasal obstruction, epistaxis, and rhinorrhea. The diagnosis is established through histopathological examination.
View Article and Find Full Text PDFExpanding the spectrum of low-grade sinonasal adenocarcinoma with biphasic seromucinous differentiation and activating HRAS/AKT1 mutations.
Histopathology
December 2024
Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland.
Aims: Low-grade non-intestinal-type sinonasal adenocarcinoma (LGSNAC) is a rare heterogeneous and poorly characterised group of tumours, distinct from intestinal- and salivary-type neoplasms. Therefore, further characterisation is needed for clearer biological understanding and classification.
Methods And Results: Clinical, histological and molecular characterisation of four cases of biphasic, low-grade adenocarcinomas of the sinonasal tract was performed.
Non-intestinal-type adenocarcinoma of the nasal cavity and paranasal sinuses: an analysis of clinical characteristics and prognosis.
Eur Arch Otorhinolaryngol
September 2024
Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University), Ministry of Education, Capital Medical University, 1, Dong Jiao Min Xiang Street, Dong Cheng District, Beijing, 100730, China.
Background: Non‑intestinal adenocarcinoma of the nasal cavity and paranasal sinuses (non‑ITAC) is a heterogeneous tumour that has rarely been reported in previous studies. We compared and analysed the symptoms, radiographic and pathological features, treatment methods, and prognosis of patients with low-grade (G1) and high-grade (G3) tumours.
Methods: This was a retrospective study included 22 patients with pathologically confirmed non-ITAC of the nasal cavity and paranasal sinuses who were treated between January 2008 and December 2021 at a single centre.
Low-grade sinonasal non-intestinal-type adenocarcinoma: a rare case report and literature review.
J Surg Case Rep
December 2023
Department of Pathology and Laboratory Medicine, Ministry of National Guard, Ar Rimayah, Riyadh 14812, Saudi Arabia.
Sinonasal non-intestinal-type adenocarcinoma is a rare but important differential diagnosis in patients presenting with recurrent, unexplained epistaxis. Low-grade types have a more favourable prognosis as opposed to the more aggressive high-grade. Symptoms include nasal obstruction and epistaxis that can last up to 5 years.
View Article and Find Full Text PDFChallenging differential diagnoses in small biopsies from the sinonasal tract.
Semin Diagn Pathol
September 2023
Department of Anatomic Pathology, Robert. J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, 9500 Euclid Ave, L2, Cleveland, OH 44195, USA. Electronic address:
Article Synopsis
- Sinonasal biopsies are complex due to their small size and the rarity of associated tumors, making assessment difficult.
- Many tumors in this region have similar appearance and immunophenotypes, so immunohistochemistry is often essential for accurate diagnosis.
- The review categorizes challenging sinonasal tumors by their morphological patterns, including low-grade squamoid lesions, glandular neoplasms, high-grade carcinomas, small round blue cell tumors, and low-grade spindle cell neoplasms.
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