AI Article Synopsis
- Trastuzumab deruxtecan (DS-8201) is an advanced cancer treatment combining an anti-HER2 antibody, a special linker, and a strong cancer-fighting drug, showing success in treating HER2-positive breast and gastric cancers.
- The presence of HER2 positivity in biliary tract cancer (BTC) ranges from 5-20%, and there's emerging evidence that HER2 inhibitors could be effective for HER2-positive BTC patients.
- The phase II HERB trial aims to assess how well trastuzumab deruxtecan works and its safety for patients with unresectable or recurrent HER2-expressing BTC, focusing on measuring the overall response rate in these patients.*
Article Abstract
Trastuzumab deruxtecan (DS-8201) is an antibody-drug conjugate composed of a humanized monoclonal anti-HER2 antibody, a cleavable tetrapeptide-based linker and a potent topoisomerase I inhibitor. The drug's efficacy has been proven in HER2-positive breast and gastric cancers. The rate of HER2 positivity in biliary tract cancer (BTC) has been reported to be 5-20%, and case reports and clinical trials have suggested that HER2 inhibitors might be active in HER2-positive BTC. Here we describe the rationale and design of the phase II HERB trial that will evaluate the efficacy and safety of trastuzumab deruxtecan in patients with HER2-expressing unresectable or recurrent BTC. The primary end point will be the centrally assessed objective response rate in HER2-positive patients.
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| http://dx.doi.org/10.2217/fon-2022-0214 | DOI Listing |
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