This study reports a case of multisystem inflammatory syndrome in children (MIS-C). Although MIS-C is currently not widespread in Japan, it is important to consider this syndrome, particularly when the patient is younger than 21 years and presents with fever and shock symptoms associated with COVID-19. According to the latest statistics updated by the Centers for Disease Control and Prevention in early 2021, the total number of MIS-C patients is only 1659 and there have been no reports from Japan. Therefore, information to accurately diagnose MIS-C is needed. This study is the first case report of MIS-C in Japan, and it proposes information to identify this serious syndrome.
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http://dx.doi.org/10.7759/cureus.23682 | DOI Listing |
Background: Type 2 diabetes mellitus (T2DM) is among the modifiable risk factors for Alzheimer's disease (AD) and ranks among the leading chronic diseases globally. It is characterized by elevated blood glucose levels and insulin resistance, which over time may impair memory performance. More so, saliva appears to be a promising biomarker for the diagnosis of AD since conventional methods appear invasive and expensive in the country.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Wake Forest Alzheimer's Disease Research Center, Winston-Salem, NC, USA.
Background: Diet composition is associated with neurodegenerative disease risk including Alzheimer's Disease (AD). The adverse effects of Western-style diets may be moderated, in part, by systemic as well as central inflammation, whereas the neuroprotective effects of Mediterranean diets may work through mechanisms that promote anti-inflammatory phenotypes. Systemic inflammation also may induce insulin resistance, another risk factor for AD.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
Background: COVID-19, identified as the greatest health concern of the century, is associated with vascular inflammation and endothelial activation, resulting in multisystemic damage, including to the central nervous system (CNS). Recent investigations indicate a link between endothelial dysfunction, neurological changes, and the development of the so-called long-COVID. Molecules expressed in the endothelium such as P-selectin, E-selectin, and VEGF-A, increased under inflammatory injury, may be associated with conditions like brain injuries and neurodegenerative diseases.
View Article and Find Full Text PDFBackground: Alzheimer's affects women 2:1 compared to men, suggesting sex-specific factors driving risk. Menopause, a female-specific phenomenon, induces a multi-system response across endocrine, metabolic, and immune-inflammatory systems. Despite known effects on these systems, the impact on the brain and AD risk remains incompletely understood, limiting preventative options.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Colorectal Surgery, Jiangsu Province Hospital of Chinese Medicine, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029, PR China.
Inflammatory bowel disease (IBD) is a multisystem condition that could affect the cutaneous systems, namely cutaneous extraintestinal manifestations (EIMs). It has been suggested that IBD is associated with erythema nodosum (EN), malignant melanoma (MM) and non-melanoma skin cancer (NMSC). However, the potential causal relationship between IBD and the mentioned above cutaneous EIMs is still unclear.
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