Herein we describe the first construction of fluorinated tertiary stereocenters based on an alkene C(sp)-C(sp) bond cleavage. The new process, that takes advantage of a Rh-catalyzed carbyne transfer, relies on a branched-selective fluorination of tertiary allyl cations and is distinguished by a wide scope including natural products and drug molecule derivatives as well as adaptability to radiofluorination.
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| http://dx.doi.org/10.1039/d2sc00968d | DOI Listing |
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