The human gut microbiome (GM) is a complex ecosystem that includes numerous prokaryotic and eukaryotic inhabitants. The composition of GM can influence an array of host physiological functions including immune development. Accumulating evidence suggest that several members of non-bacterial microbiota, including protozoa and helminths, that were earlier considered as pathogens, could have a commensal or beneficial relationship with the host. Here we examine the most recent data from omics studies on prokaryota-meiofauna-host interaction as well as the impact of gut parasitome on gut bacterial ecology and its role as 'immunological driver' in health and disease to glimpse new therapeutic perspectives.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9058362 | PMC |
| http://dx.doi.org/10.1177/17562848221091524 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effects of Lactiplantibacillus plantarum and Lacticaseibacillus paracasei supplementation on the single-cell fecal parasitome in children with celiac disease autoimmunity: a randomized, double-blind placebo-controlled clinical trial.
Parasit Vectors
November 2023
Celiac Disease and Diabetes Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden.
Article Synopsis
- Lactiplantibacillus plantarum HEAL9 and Lacticaseibacillus paracasei 8700:2 were studied for their effects on single-cell parasites, specifically Blastocystis, in children with celiac disease autoimmunity after 6 months of supplementation.
- A total of 78 Swedish children participated in a randomized trial, with stool samples analyzed for parasite presence using advanced sequencing methods.
- The study found three single-cell protists, notably Dientamoeba fragilis and Blastocystis, but no significant changes in their levels were observed due to probiotic use; however, the presence of these protists was linked to increased diversity in the gut bacteria.
Mood Disorders: The Gut Bacteriome and Beyond.
Biol Psychiatry
February 2024
Food and Mood Centre, Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, Australia; Centre for Adolescent Health, Murdoch Children's Research Institute, Melbourne, Victoria, Australia; College of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville, Queensland, Australia.
Knowledge of the microbiome-gut-brain axis has revolutionized the field of psychiatry. It is now well recognized that the gut bacteriome is associated with, and likely influences, the pathogenesis of mental disorders, including major depressive disorder and bipolar disorder. However, while substantial advances in the field of microbiome science have been made, we have likely only scratched the surface in our understanding of how these ecosystems might contribute to mental disorder pathophysiology.
View Article and Find Full Text PDFGut microbes and host behavior: The forgotten members of the gut-microbiome.
Neuropharmacology
April 2023
Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel. Electronic address:
The gut microbiota refers to an entire population of microorganisms that colonize the gut. This community includes viruses, prokaryotes (bacteria and archaea), and eukaryotes (fungi and parasites). Multiple studies in the last decades described the significant involvement of gut bacteria in gut-brain axis communication; however, the involvement of other members of the gut microbiota has been neglected.
View Article and Find Full Text PDFHow the gut parasitome affects human health.
Therap Adv Gastroenterol
April 2022
Gastroenterology Unit, Fondazione Policlinico Gemelli IRCCS, Roma, Italy.
The human gut microbiome (GM) is a complex ecosystem that includes numerous prokaryotic and eukaryotic inhabitants. The composition of GM can influence an array of host physiological functions including immune development. Accumulating evidence suggest that several members of non-bacterial microbiota, including protozoa and helminths, that were earlier considered as pathogens, could have a commensal or beneficial relationship with the host.
View Article and Find Full Text PDFClinical Parasitology and Parasitome Maps as Old and New Tools to Improve Clinical Microbiomics.
Pathogens
November 2021
Microbiology and Diagnostic Immunology Unit, Unit of Microbiomics, Bambino Gesù Children's Hospital, IRCCS, 00146 Rome, Italy.
A growing body of evidence shows that dysbiotic gut microbiota may correlate with a wide range of disorders; hence, the clinical use of microbiota maps and fecal microbiota transplantation (FMT) can be exploited in the clinic of some infectious diseases. Through direct or indirect ecological and functional competition, FMT may stimulate decolonization of pathogens or opportunistic pathogens, modulating immune response and colonic inflammation, and restoring intestinal homeostasis, which reduces host damage. Herein, we discuss how diagnostic parasitology may contribute to designing clinical metagenomic pipelines and FMT programs, especially in pediatric subjects.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!