AI Article Synopsis
- - The research reveals that genetic changes in specific regulatory elements (WT box and W box) of the RAP2.12 gene link to how certain species adapt to varying environmental stresses like drought and flooding.
- - Different transcription factors control these regulatory elements, leading to the selective accumulation of gene transcripts that respond to low oxygen levels.
- - The study suggests that the transition between different gene regulatory variants is tied to species moving from dry to more humid environments, highlighting a complex adaptation strategy influenced by noncoding genetic variations.
Article Abstract
Populations of widespread species are usually geographically distributed through contrasting stresses, but underlying genetic mechanisms controlling this adaptation remain largely unknown. Here, we show that in , allelic changes in the cis-regulatory elements, WT box and W box, in the promoter of a key transcription factor associated with oxygen sensing, RELATED TO AP 2.12 (RAP2.12), are responsible for differentially regulating tolerance to drought and flooding. These two cis-elements are regulated by different transcription factors that downstream of results in differential accumulation of hypoxia-responsive transcripts. The evolution from one cis-element haplotype to the other is associated with the colonization of humid environments from arid habitats. This gene thus promotes both drought and flooding adaptation via an adaptive mechanism that diversifies its regulation through noncoding alleles.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9067915 | PMC |
| http://dx.doi.org/10.1126/sciadv.abn8281 | DOI Listing |
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