AI Article Synopsis
- Scientists studied how people's previous infections with seasonal coronaviruses affect their response to SARS-CoV-2, the virus that causes COVID-19.
- They used a special technique to look at how antibodies target different parts of the virus spikes.
- The researchers found that most people had antibodies from earlier coronaviruses, which worked differently than those found in people who had recovered from COVID-19.
Article Abstract
Preexisting immunity against seasonal coronaviruses (CoVs) represents an important variable in predicting antibody responses and disease severity to severe acute respiratory syndrome CoV-2 (SARS-CoV-2) infections. We used electron microscopy-based polyclonal epitope mapping (EMPEM) to characterize the antibody specificities against β-CoV spike proteins in prepandemic (PP) sera or SARS-CoV-2 convalescent (SC) sera. We observed that most PP sera had antibodies specific to seasonal human CoVs (HCoVs) OC43 and HKU1 spike proteins while the SC sera showed reactivity across all human β-CoVs. Detailed molecular mapping of spike-antibody complexes revealed epitopes that were differentially targeted by preexisting antibodies and SC serum antibodies. Our studies provide an antigenic landscape to β-HCoV spikes in the general population serving as a basis for cross-reactive epitope analyses in SARS-CoV-2-infected individuals.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9067923 | PMC |
| http://dx.doi.org/10.1126/sciadv.abn2911 | DOI Listing |
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