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Correction to: Carnosic acid potentiates the anticancer effect of temozolomide by inducing apoptosis and autophagy in glioma.
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species have a longstanding traditional culinary use, mostly being consumed in the Mediterranean diet as a common herb added to food. is commonly consumed as a herbal tea for memory enhancement. Alzheimer's disease (AD) is the most prevalent form of dementia affecting people worldwide Therefore, the current research aimed to investigate potential therapeutic benefits of (SOL) cultivated in Jordan and (SML) cultivated in Egypt with regard to acetylcholinesterase activity, β-amyloid deposition and oxidative stress associated with scopolamine-induced AD.
View Article and Find Full Text PDFHypersensitivity of BRCA2 deficient cells to rosemary extract explained by weak PARP inhibitory activity.
Sci Rep
December 2017
Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, 80523, USA.
Rosemary extract is used in food additives and traditional medicine and has been observed to contain anti-tumor activity. In this study, rosemary extract is hypothesized to induce synthetic lethality in BRCA2 deficient cells by PARP inhibition. Chinese hamster lung V79 cells and its mutant cell lines, V-C8 (BRCA2 deficient) and V-C8 with BRCA2 gene correction were used.
View Article and Find Full Text PDF[Corrigendum] Carnosic acid induces apoptosis through inactivation of Src/STAT3 signaling pathway in human renal carcinoma Caki cells.
Oncol Rep
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College of Pharmacy, Keimyung University, Daegu 704-701, Republic of Korea.
After carefully checking the original data of ROS generation experiment, we found that in Fig. 3E the x-axis was incorrently labeled. ISL should be substituted with CA.
View Article and Find Full Text PDFProapoptotic, anti-cell proliferative, anti-inflammatory and anti-angiogenic potential of carnosic acid during 7,12 dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis.
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Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar - 608 002.
The present study has investigated the modulating effect of carnosic acid on the expression pattern of cell proliferative (proliferating cell nuclear antigen (PCNA) cyclin D1 and a transcription factor c-fos), apoptotic (p53, Bcl-2, Bax caspase -3 and 9), inflammatory (Nuclear factor kappa B (NFκB) and cyclooxygenase-2 (COX- 2) and angiogenic (vascular endothelial growth factor (VEGF) markers during 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch carcinogenesis. Oral tumors were developed in the hamsters buccal pouches by painting with 0.5% DMBA in liquid paraffin three times a week for 14 weeks.
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