AI Article Synopsis
- Bendamustine is an alkylating agent, part of nitrogen mustard analogues, that was first synthesized nearly 60 years ago and approved for use in the US in 2008 for specific types of cancers.
- It has shown promising results in treating relapsed or refractory hematological cancers and exhibits synergistic effects with other cancer drugs, drawing renewed interest in its application.
- The review highlights bendamustine's unique structure, its pharmacokinetics, mechanism of action, toxicity, and unexplored immune-modulating effects, encouraging more research into its potential in oncology.
Article Abstract
Bendamustine is an alkylating agent classified into the group of nitrogen mustard analogues, synthesized almost sixty years ago. It was registered in former East Germany in 1971 and approved by the US Food and Drug Administration in 2008 for treatment of chronic lymphocytic leukemia and indolent B‑cell non‑Hodgkin lymphoma. Considering its beneficial properties in the therapy of relapsed or refractory hematological malignancies, synergistic effects with other antineoplastic agents and increasing recent reports on its immunomodulatory effects, bendamustine has once again gained its justified attention. The uniqueness of bendamustine‑mediated effects should be observed keeping in mind its distinctive structure with structural similarities to both alkylating agents and purine analogs. In the present review, the current knowledge on the use of bendamustine in oncology, its pharmacokinetics, mechanism of action and toxicity was summarized. In addition, its immune‑modulating effects that have not been fully elucidated so far are emphasized, hoping to encourage further investigations of this unique drug.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9100486 | PMC |
| http://dx.doi.org/10.3892/or.2022.8325 | DOI Listing |
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