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Metastatic multicentric epithelioid angiosarcoma of bone. A case report with pitfalls. Tumor seeding after percutaneous biopsy and hypercalcemia.
J Surg Case Rep
January 2025
Orthopaedic Oncologist Unit, La Paz University Hospital, P° Castellana 261, 28046 Madrid, Spain.
Angiosarcomas are a type of malignant tumor of vascular origin. They represent <1% of all primary bone tumors. The multicentric or metastatic does not differ in its high aggressiveness and poor prognosis.
View Article and Find Full Text PDFMyxofibrosarcoma with epithelioid morphology: A clinicopathological study of 44 cases with emphasis on differential diagnosis.
Histopathology
November 2024
Department of Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland, OH, USA.
Article Synopsis
- - The study focused on 44 cases of epithelioid myxofibrosarcoma (eMFS), a rare and aggressive cancer variant, examining factors like morphologic structure and cancer grading, revealing that the majority displayed diffuse epithelioid characteristics and high FNCLCC grades.
- - Among the patients, mostly older adults with a higher incidence in males, local recurrence and metastasis were common; specifically, 10 out of 22 monitored patients developed metastases, typically to regional lymph nodes, regardless of tumor grade.
- - An interesting note is that some cases initially diagnosed as eMFS shared genetic mutations typically seen in other UV-driven cancers, suggesting possible misdiagnosis and the need for careful evaluation
Malignant Bone-Forming Neoplasm With NIPBL::BEND2 Fusion.
Genes Chromosomes Cancer
November 2024
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Conventional high-grade osteosarcomas are characterized by aggressive radiologic features, cytologic pleomorphism, and complex genomics. However, rare examples of osteosarcomas remain challenging due to unusual histology, such as sclerosing or osteoblastoma-like features, which may require molecular confirmation of their complex genetic alterations. We have encountered such a case in a 17-year-old man, who presented with a third metatarsal sclerotic bone lesion, found incidentally in the work-up of a foot trauma.
View Article and Find Full Text PDFProximal and Classic Epithelioid Sarcomas are Distinct Molecular Entities Defined by MYC/GATA3 and SOX17/Endothelial Markers, Respectively.
Mod Pathol
November 2024
Unit of Oncogenetics and Functional Oncogenomics, Centro di Riferimento Oncologico di Aviano (CRO Aviano) IRCCS, National Cancer Institute, Aviano, Italy. Electronic address:
Epithelioid sarcoma (ES) is a rare tumor hallmarked by the loss of INI1/SMARCB1 expression. Apart from this alteration, little is known about the biology of ES. Despite recent advances in treatment, the prognosis of ES remains unsatisfactory.
View Article and Find Full Text PDFTubercular dactylitis/Spina ventosa-A rare skeletal form of extrapulmonary tuberculosis.
QJM
November 2024
Department of Cytology and Gynecological Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Article Synopsis
- A 9-year-old girl presented with painful swelling in her left index finger, which was punctured, leading to a chronic discharging sinus and other systemic symptoms like lymphadenopathy.
- A Mantoux test confirmed tuberculosis, and a fine aspiration showed signs of inflammation and acid-fast bacilli.
- After being started on a 4-drug antitubercular therapy, she showed significant improvement in pain and swelling within two months, highlighting the condition known as tubercular dactylitis which primarily affects younger children and presents as swelling of tubular bones.
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