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Biomarkers.
Alzheimers Dement
December 2024
Alzheimer Center Amsterdam, Amsterdam UMC, Amsterdam, Netherlands.
Background: Recent advancements in Alzheimer's disease (AD) biomarker research and AD drug trials prompt reflection on the value and appropriate use of tau-PET in future clinical practice and trials. We therefore conducted a survey among dementia and PET experts worldwide to investigate how they envision the future role of tau-PET in clinical practice and trials.
Method: An online survey was distributed to dementia clinicians and researchers who were invited to participate through personalized emails, social media channels and/or presentations at relevant conferences.
Background: Members of the Fire Department of New York (FDNY) who responded to the World Trade Center (WTC) attacks that occurred on 9/11/2001 were exposed to severe trauma. The present study screened for cognitive impairment in a prospective cohort study of FDNY fire fighters and emergency personnel who reside in the greater NYC metropolitan area.
Method: A large sample (n = 338) of FDNY personnel who were exposed to the WTC attacks were recruited to complete a large battery of neuropsychiatric and psychological tests.
Public Health.
Alzheimers Dement
December 2024
Hospital Alemão Oswaldo Cruz, São Paulo, São Paulo, Brazil.
Background: In Brazil, the dementia landscape is projected to intensify significantly, with the number of people living with dementia expected to more than triple by 2050. This anticipated surge underscores the urgency for health and social systems to strategize and prepare adequately. However, studies about costs related to dementia are very scarce in Brazil, making it difficult to understand better the financial impacts of the syndrome.
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Alzheimers Dement
December 2024
Hospital de Clínicas, Montevideo, Montevideo, Uruguay.
Background: The choice of tests and batteries for cognitive evaluation in neuropsychology is biased by a central aspect of each patient, their educational level. This can be very different between cultures, and is particularly low in some regions of Latin America. This population characteristic generates limitations in the tests that we can perform in some patients with a low educational level.
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Alzheimers Dement
December 2024
University of Pennsylvania, Philadelphia, PA, USA.
Background: Recent genome-wide association studies (GWAS) of Alzheimer's disease (AD) have identified approximately 70 genetic loci linked to the disorder. The pivotal challenge in the post-GWAS era is dissecting the underlying causal variants and effector genes, a crucial step for effective therapeutic development. Most of these variants reside in non-coding regions of the genome, suggesting their regulatory role in distal gene expression.
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