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[Flocculation of NPH insulin].
Rev Clin Esp
January 1994
Servicio de Endocrinología, Hospital Miguel Servet, Zaragoza.
In the past decade, human insulins have been substituting animal insulins, offering the advantage of its lesser antigenic capacity. One of the most clinically important problems with human NPH insulins is its tendency to flocculate. We present four diabetic patients who, after using flocculated human NPH insulin, encountered a deterioration in the metabolic control of their diabetes, and in two of them, there were bouts of diabetic Ketoacidosis "without any other apparent causal factors".
View Article and Find Full Text PDFFlocculation and loss of potency of human NPH insulin.
Diabetes Care
February 1989
Virginia Mason Clinic, Section of Endocrinology and Diabetes, Seattle, WA 98111.
In late 1986, several vials of Humulin N (NPH human insulin, recombinant DNA origin) came to our attention because of a clumped, white coating on the inside of the vials. To determine the frequency of this phenomenon, we surveyed 100 consecutive patients who used Humulin N. Ten patients had encountered 21 vials of flocculated insulin in the previous 12 mo, reflecting an incidence of 1 per 72 vials.
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