Background: The aim of the work is to compare the characteristics of quality of life and mental disorders in patients in the group with isolated gastroesophageal reflux disease (GERD) and in patients with combined pathology (GERD in combination with hypothyroidism).

Methods: Symptomatic questionnaire of Yu. Alexandrovich and questionnaire SF-36 were used. The survey was conducted in 124 patients aged 18 to 65 years.

Results: Anxiety disorders are the most common among the mental disorders in patients with GERD, depressive and psychasthenic disorders - in patients with combined pathology. All indicators of quality of life were lower in patients with combined pathology.

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