[Clinico-radiological assessment of the effectiveness of pathogenetic therapy in glomerulonephritis in children].

Liver scintigraphy and hepatobiliary scintigraphy were employed for the assessment of kidney and liver function in children with glomerulonephritis at the stages of pathogenetic therapy with chlorambucil and prednisolone. Noticeable disturbance of nephron and hepatocytic function at the climax of clinical manifestations of the nephrotic syndrome was established. The use of maximum and maintenance doses of prednisolone and chlorambucil resulted in significant improvement of clinical and radionuclide indices. However the effective renal plasma flow and the rate of passage of the radionuclide from the plasma into the proximal canalicular cell did not return to normal even in the catamnesis 1 year after the discontinuation of treatment in 35% of the patients with chronic glomerulonephritis. The use of maximum doses of cytostatics in 98.5% of the children produced no damaging effect on the hepatocyte, in 1.5% of the children the authors observed the development of drug hepatitis. Hypokinetic dyskinesia of the gall bladder was detected in the overwhelming majority of the patients therefore drugs improving bile secretion should be recommended as part of treatment.